天然产物对肿瘤微环境中髓源性抑制细胞的调节

IF 2.9 4区医学 Q3 IMMUNOLOGY

Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2023-07-06 DOI:10.1007/s00005-023-00681-0

Jhon Jairo Calderon, Karol Prieto, Paola Lasso, Susana Fiorentino, Alfonso Barreto

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引用次数: 2

摘要

在癌变过程中，微环境在肿瘤的进展和耐药性中起着重要作用。这种肿瘤微环境(TME)在大多数情况下具有高度免疫抑制的特点，这使其成为开发新疗法的重要靶点。在TME中协调免疫抑制的最重要的细胞群之一是髓源性抑制细胞(MDSCs)，它具有多种机制来抑制T淋巴细胞介导的免疫反应，从而保护肿瘤。在这篇综述中，我们将讨论调节MDSCs作为治疗靶点的重要性，以及如何使用天然产物，由于其多种作用机制，可以成为调节这些细胞的关键替代方案，从而提高癌症患者对治疗的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Modulation of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment by Natural Products

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Modulation of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment by Natural Products

During carcinogenesis, the microenvironment plays a fundamental role in tumor progression and resistance. This tumor microenvironment (TME) is characterized by being highly immunosuppressive in most cases, which makes it an important target for the development of new therapies. One of the most important groups of cells that orchestrate immunosuppression in TME is myeloid-derived suppressor cells (MDSCs), which have multiple mechanisms to suppress the immune response mediated by T lymphocytes and thus protect the tumor. In this review, we will discuss the importance of modulating MDSCs as a therapeutic target and how the use of natural products, due to their multiple mechanisms of action, can be a key alternative for modulating these cells and thus improve response to therapy in cancer patients.

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来源期刊

Archivum Immunologiae et Therapiae Experimentalis 医学-免疫学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.