磁共振弹性成像与超声剪切波弹性成像在怀疑非酒精性脂肪肝患者中的比较

IF 0.7 4区 医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Aylin Tahmasebi, Corinne E Wessner, Flavius F Guglielmo, Shuo Wang, Trang Vu, Ji-Bin Liu, Jesse Civan, Andrej Lyshchik, Flemming Forsberg, Hongbo Li, Enze Qu, John R Eisenbrey
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引用次数: 1

摘要

摘要:本研究探讨磁共振弹性成像(MRE)与剪切波超声弹性成像(SWE)在临床诊断或疑似非酒精性脂肪性肝病(NAFLD)患者中的相关性。通过磁共振成像(MRI)质子密度脂肪分数(PDFF)确定的NAFLD患者或有NAFLD风险的受试者被前瞻性纳入研究。对于每位患者,使用Logiq E10扫描仪(GE HealthCare, Waukesha, WI)获得6个有效的二维SWE测量值。SWE采用四分位数间距与中位数之比≤15%的信度标准来表示数据集的质量。作为患者临床标准护理的一部分,磁共振弹性成像和核磁共振脂肪定量数据在同一天收集。以磁共振成像PDFF为参考,定量脂肪,大于6.4%为NAFLD。采用Pearson相关和t检验进行统计分析。共纳入140例患者,其中112例符合SWE可靠性测量标准。磁共振弹性成像和二维SWE在所有研究对象中显示正相关(r = 0.27;P = 0.004)。根据脂肪变性和纤维化状态对患者进行分组时,纤维化患者的MRE与SWE呈正相关(r = 0.30;P = 0.03),无纤维化(r = 0.27;P = 0.03), NAFLD患者(r = 0.28;P = 0.02)。肝脂肪定量与弹性成像无相关性(P > 0.52)。有无纤维化患者的磁共振弹性成像差异有统计学意义(P < 0.0001)。但SWE组差异不明显(P = 0.09)。在疑似或已知NAFLD的患者中,MRE和SWE表现出正相关。此外,这些无创成像方式可能是监测NAFLD的有用辅助技术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of Magnetic Resonance-Based Elastography and Ultrasound Shear Wave Elastography in Patients With Suspicion of Nonalcoholic Fatty Liver Disease.

Abstract: This study investigated the correlation between magnetic resonance elastography (MRE) and shear wave ultrasound elastography (SWE) in patients with clinically diagnosed or suspected nonalcoholic fatty liver disease (NAFLD). Subjects with or at risk of NAFLD identified by magnetic resonance imaging (MRI) proton density fat fraction (PDFF) were prospectively enrolled. For each patient, 6 valid 2-dimensional SWE measurements were acquired using a Logiq E10 scanner (GE HealthCare, Waukesha, WI). A reliability criterion of an interquartile range to median ratio of ≤15% was used for SWE to indicate quality dataset. Magnetic resonance elastography, and MR-fat quantification data were collected the same day as part of the patient's clinical standard of care. Magnetic resonance imaging PDFF was used as a reference to quantify fat with >6.4% indicating NAFLD. Pearson correlation and t-test were performed for statistical analyses. A total of 140 patients were enrolled, 112 of which met SWE reliability measurement criteria. Magnetic resonance elastography and 2-dimensional SWE showed a positive correlation across all study subjects ( r = 0.27; P = 0.004). When patients were grouped according to steatosis and fibrosis state, a positive correlation was observed between MRE and SWE in patients with fibrosis ( r = 0.30; P = 0.03), without fibrosis ( r = 0.27; P = 0.03), and with NAFLD ( r = 0.28; P = 0.02). No elastography technique correlated with liver fat quantification ( P > 0.52). Magnetic resonance elastography was significantly different between patients with and without fibrosis ( P < 0.0001). However, this difference was not apparent with SWE ( P = 0.09). In patients with suspected or known NAFLD, MRE, and SWE demonstrated a positive correlation. In addition, these noninvasive imaging modalities may be useful adjunct techniques for monitoring NAFLD.

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来源期刊
Ultrasound Quarterly
Ultrasound Quarterly RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.50
自引率
7.70%
发文量
105
审稿时长
>12 weeks
期刊介绍: Ultrasound Quarterly provides coverage of the newest, most sophisticated ultrasound techniques as well as in-depth analysis of important developments in this dynamic field. The journal publishes reviews of a wide variety of topics including trans-vaginal ultrasonography, detection of fetal anomalies, color Doppler flow imaging, pediatric ultrasonography, and breast sonography. Official Journal of the Society of Radiologists in Ultrasound
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