叙述性综述:芬特明和托吡酯治疗小儿肥胖症。

IF 1.7 Q2 PEDIATRICS
Adolescent Health Medicine and Therapeutics Pub Date : 2023-08-23 eCollection Date: 2023-01-01 DOI:10.2147/AHMT.S383454
Anthony Kim, Jennifer Nguyen, Mahsa Babaei, Ahlee Kim, David H Geller, Alaina P Vidmar
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引用次数: 0

摘要

在过去的四十年里,小儿肥胖症的发病率呈指数级增长。美国儿科学会最近发布了最新的临床实践指南,强调将小儿肥胖症确定为慢性疾病的重要性。该指南支持考虑同时采用强化生活方式干预、肥胖症药物疗法和减肥手术进行治疗。小儿肥胖症的急剧增加激发了人们对利用肥胖症药物疗法来支持小儿群体持续减轻体重的兴趣,希望以此来预防日后出现的严重并发症。尽管需求巨大,但在儿科人群中开展所需的临床试验所面临的障碍明显限制了用于治疗儿科肥胖症的药物疗法。目前,美国食品和药物管理局批准了五种药物用于青少年肥胖症患者。2022 年,芬特明/托吡酯(PHEN/TPM)这种每日一次、控释的复方产品获得了美国食品及药物管理局的批准,用于 12 岁及以上肥胖症青少年的慢性体重管理。本综述旨在(1)回顾芬特明和托吡酯的作用机制;(2)总结托吡酯和芬特明作为单一疗法和联合疗法的安全性和有效性数据;(3)讨论在肥胖症青少年中使用这些药物的临床实践指南和临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Narrative Review: Phentermine and Topiramate for the Treatment of Pediatric Obesity.

The prevalence of pediatric obesity has increased exponentially over the past four decades. The American Academy of Pediatrics recently released updated clinical practice guidelines highlighting the importance of identifying pediatric obesity as a chronic disease. The guidelines support consideration of concurrent treatment with intensive lifestyle interventions, obesity pharmacotherapy, and bariatric surgery. The dramatic rise in pediatric obesity has spurred interest in utilizing obesity pharmacotherapy to support sustained weight reduction in pediatric cohorts, in the hopes of preventing the emergence of later-appearing, significant co-morbidities. Despite the enormous demand, the obstacles posed by performance of needed clinical trials in the pediatric population markedly limits available pharmacotherapy for the treatment of obesity in pediatrics. Currently, there are five medications approved by the Food and Drug Administration for use in youth with obesity. In 2022, the phentermine/topiramate (PHEN/TPM), once-daily, controlled-release, combination product received FDA approval, for the indication of chronic weight management, in youth with obesity, ages 12 years and older. The objectives of this narrative review are to: (1) Review the mechanism of action of phentermine and topiramate, (2) Summarize the safety and efficacy data of topiramate and phentermine use as both monotherapies and in combination, and (3) Discuss clinical practice guidelines and clinical implications, for the use of these agents in youths with obesity.

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来源期刊
自引率
0.00%
发文量
13
审稿时长
16 weeks
期刊介绍: Adolescent Health, Medicine and Therapeutics is an international, peer reviewed, open access journal focusing on health, pathology, and treatment issues specific to the adolescent age group, including health issues affecting young people with cancer. Original research, reports, editorials, reviews, commentaries and adolescent-focused clinical trial design are welcomed. All aspects of health maintenance, preventative measures, disease treatment interventions, studies investigating the poor outcomes for some treatments in this group of patients, and the challenges when transitioning from adolescent to adult care are addressed within the journal. Practitioners from all disciplines are invited to submit their work as well as health care researchers and patient support groups. Areas covered include: Physical and mental development in the adolescent period, Behavioral issues, Pathologies and treatment interventions specific to this age group, Prevalence and incidence studies, Diet and nutrition, Specific drug handling, efficacy, and safety issues, Drug development programs, Outcome studies, patient satisfaction, compliance, and adherence, Patient and health education programs and studies.
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