莫桑比克莫佩亚毒蛇咬伤的负担和风险因素:利用更大规模的疟疾试验来生成这种被忽视的热带疾病的数据。

IF 3.8 2区 医学 Q1 Medicine
PLoS Neglected Tropical Diseases Pub Date : 2023-08-17 eCollection Date: 2023-08-01 DOI:10.1371/journal.pntd.0011551
Emma O'Bryan, Saimado Imputiua, Eldo Elobolobo, Patricia Nicolas, Julia Montana, Edgar Jamisse, Humberto Munguambe, Aina Casellas, Paula Ruiz-Castillo, Regina Rabinovich, Francisco Saute, Charfudin Sacoor, Carlos Chaccour
{"title":"莫桑比克莫佩亚毒蛇咬伤的负担和风险因素:利用更大规模的疟疾试验来生成这种被忽视的热带疾病的数据。","authors":"Emma O'Bryan,&nbsp;Saimado Imputiua,&nbsp;Eldo Elobolobo,&nbsp;Patricia Nicolas,&nbsp;Julia Montana,&nbsp;Edgar Jamisse,&nbsp;Humberto Munguambe,&nbsp;Aina Casellas,&nbsp;Paula Ruiz-Castillo,&nbsp;Regina Rabinovich,&nbsp;Francisco Saute,&nbsp;Charfudin Sacoor,&nbsp;Carlos Chaccour","doi":"10.1371/journal.pntd.0011551","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Snakebite is a neglected disease that disproportionally affects the rural poor. There is a dearth of evidence regarding incidence and risk factors in snakebite-endemic countries. Without this basic data, it will be impossible to achieve the target of a 50% reduction of snakebite morbidity and mortality by 2030 as set by the World Health Organization.</p><p><strong>Methods: </strong>This was a descriptive analysis nested in a 2021 community-based demographic survey of over 70,000 individuals conducted in Mopeia, Mozambique, in preparation for a cluster randomized trial to test an intervention for malaria. We describe the incidence rate, demographics, socioeconomic indicators and outcomes of snakebite in this population.</p><p><strong>Findings: </strong>We found the incidence of self-reported snakebite in Mopeia to be 393 bites per 100,000 person-years at risk, with 2% of households affected in the preceding 12 months. Whilst no fatalities were recorded, over 3,000 days of work or school days were lost with an individual household economic impact higher than that of uncomplicated malaria. 1 in 6 of those affected did not fully recover at the time of the study. We found significant relationships between age older than 15, use of firewood for household fuel, and animal possession with snakebite.</p><p><strong>Conclusions: </strong>This study exposes higher than expected incidence and burden of snakebite in rural Mozambique. Whilst snakebite elimination in Mozambique seems unattainable today, it remains a preventable disease with manageable sequelae. We have shown that snakebite research is particularly easy to nest in larger studies, making this a practical and cost-effective way of estimating its incidence.</p>","PeriodicalId":20260,"journal":{"name":"PLoS Neglected Tropical Diseases","volume":"17 8","pages":"e0011551"},"PeriodicalIF":3.8000,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464960/pdf/","citationCount":"0","resultStr":"{\"title\":\"Burden and risk factors of snakebite in Mopeia, Mozambique: Leveraging larger malaria trials to generate data of this neglected tropical disease.\",\"authors\":\"Emma O'Bryan,&nbsp;Saimado Imputiua,&nbsp;Eldo Elobolobo,&nbsp;Patricia Nicolas,&nbsp;Julia Montana,&nbsp;Edgar Jamisse,&nbsp;Humberto Munguambe,&nbsp;Aina Casellas,&nbsp;Paula Ruiz-Castillo,&nbsp;Regina Rabinovich,&nbsp;Francisco Saute,&nbsp;Charfudin Sacoor,&nbsp;Carlos Chaccour\",\"doi\":\"10.1371/journal.pntd.0011551\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Snakebite is a neglected disease that disproportionally affects the rural poor. There is a dearth of evidence regarding incidence and risk factors in snakebite-endemic countries. Without this basic data, it will be impossible to achieve the target of a 50% reduction of snakebite morbidity and mortality by 2030 as set by the World Health Organization.</p><p><strong>Methods: </strong>This was a descriptive analysis nested in a 2021 community-based demographic survey of over 70,000 individuals conducted in Mopeia, Mozambique, in preparation for a cluster randomized trial to test an intervention for malaria. We describe the incidence rate, demographics, socioeconomic indicators and outcomes of snakebite in this population.</p><p><strong>Findings: </strong>We found the incidence of self-reported snakebite in Mopeia to be 393 bites per 100,000 person-years at risk, with 2% of households affected in the preceding 12 months. Whilst no fatalities were recorded, over 3,000 days of work or school days were lost with an individual household economic impact higher than that of uncomplicated malaria. 1 in 6 of those affected did not fully recover at the time of the study. We found significant relationships between age older than 15, use of firewood for household fuel, and animal possession with snakebite.</p><p><strong>Conclusions: </strong>This study exposes higher than expected incidence and burden of snakebite in rural Mozambique. Whilst snakebite elimination in Mozambique seems unattainable today, it remains a preventable disease with manageable sequelae. We have shown that snakebite research is particularly easy to nest in larger studies, making this a practical and cost-effective way of estimating its incidence.</p>\",\"PeriodicalId\":20260,\"journal\":{\"name\":\"PLoS Neglected Tropical Diseases\",\"volume\":\"17 8\",\"pages\":\"e0011551\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2023-08-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464960/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"PLoS Neglected Tropical Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1371/journal.pntd.0011551\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/8/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"PLoS Neglected Tropical Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1371/journal.pntd.0011551","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

背景:蛇咬伤是一种被忽视的疾病,对农村贫困人口的影响尤为严重。关于蛇咬伤流行国家的发病率和风险因素,缺乏证据。如果没有这些基本数据,就不可能实现世界卫生组织设定的到2030年将蛇咬伤发病率和死亡率降低50%的目标,为测试疟疾干预措施的集群随机试验做准备。我们描述了该人群中蛇咬伤的发病率、人口统计、社会经济指标和结果。研究结果:我们发现,莫佩亚自我报告的蛇咬伤发生率为每100000人-年393次,其中2%的家庭在前12个月内受到影响。虽然没有死亡记录,但损失了3000多天的工作或上学时间,个人家庭经济影响高于单纯疟疾。六分之一的受影响者在研究时没有完全康复。我们发现,15岁以上的年龄、使用木柴作为家庭燃料和蛇咬伤动物之间存在显著关系。结论:本研究揭示了莫桑比克农村地区毒蛇咬伤的发生率和负担高于预期。虽然莫桑比克目前似乎无法消除毒蛇咬伤,但它仍然是一种可预防的疾病,后遗症可控。我们已经表明,蛇咬研究特别容易在更大规模的研究中进行,这使得这成为一种实用且具有成本效益的估计其发病率的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Burden and risk factors of snakebite in Mopeia, Mozambique: Leveraging larger malaria trials to generate data of this neglected tropical disease.

Burden and risk factors of snakebite in Mopeia, Mozambique: Leveraging larger malaria trials to generate data of this neglected tropical disease.

Burden and risk factors of snakebite in Mopeia, Mozambique: Leveraging larger malaria trials to generate data of this neglected tropical disease.

Burden and risk factors of snakebite in Mopeia, Mozambique: Leveraging larger malaria trials to generate data of this neglected tropical disease.

Background: Snakebite is a neglected disease that disproportionally affects the rural poor. There is a dearth of evidence regarding incidence and risk factors in snakebite-endemic countries. Without this basic data, it will be impossible to achieve the target of a 50% reduction of snakebite morbidity and mortality by 2030 as set by the World Health Organization.

Methods: This was a descriptive analysis nested in a 2021 community-based demographic survey of over 70,000 individuals conducted in Mopeia, Mozambique, in preparation for a cluster randomized trial to test an intervention for malaria. We describe the incidence rate, demographics, socioeconomic indicators and outcomes of snakebite in this population.

Findings: We found the incidence of self-reported snakebite in Mopeia to be 393 bites per 100,000 person-years at risk, with 2% of households affected in the preceding 12 months. Whilst no fatalities were recorded, over 3,000 days of work or school days were lost with an individual household economic impact higher than that of uncomplicated malaria. 1 in 6 of those affected did not fully recover at the time of the study. We found significant relationships between age older than 15, use of firewood for household fuel, and animal possession with snakebite.

Conclusions: This study exposes higher than expected incidence and burden of snakebite in rural Mozambique. Whilst snakebite elimination in Mozambique seems unattainable today, it remains a preventable disease with manageable sequelae. We have shown that snakebite research is particularly easy to nest in larger studies, making this a practical and cost-effective way of estimating its incidence.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases Medicine-Infectious Diseases
CiteScore
7.40
自引率
10.50%
发文量
723
审稿时长
2-3 weeks
期刊介绍: PLOS Neglected Tropical Diseases publishes research devoted to the pathology, epidemiology, prevention, treatment and control of the neglected tropical diseases (NTDs), as well as relevant public policy. The NTDs are defined as a group of poverty-promoting chronic infectious diseases, which primarily occur in rural areas and poor urban areas of low-income and middle-income countries. Their impact on child health and development, pregnancy, and worker productivity, as well as their stigmatizing features limit economic stability. All aspects of these diseases are considered, including: Pathogenesis Clinical features Pharmacology and treatment Diagnosis Epidemiology Vector biology Vaccinology and prevention Demographic, ecological and social determinants Public health and policy aspects (including cost-effectiveness analyses).
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信