吊顶酶注射治疗腰椎间盘突出症的临床疗效。

IF 1.2 Q3 SURGERY
Yujiro Kagami, Hiroaki Nakashima, Naoki Segi, Ryuichi Shinjo, Shiro Imagama
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引用次数: 0

摘要

简介:本研究旨在评价吊顶酶注射治疗腰椎间盘突出症(LLDH)的疗效。方法:本回顾性研究纳入180例入组患者中的157例(男性70例,女性87例;平均年龄:52.6±16.9岁)。将患者分为两组(L组:LLDH, M组:内侧LDH[韧带下和韧带外])。从基线至注射后1年(最后随访),采用视觉模拟量表(VAS)和日本骨科协会(JOA) CIT评分评估CIT的临床疗效,并评估注射前和注射后3个月的x线片和磁共振成像。在最终随访时VAS改善≥50%的患者被定义为应答者。还比较了有反应和无反应的LLDH组。结果:L组和M组有效率相当(分别为75.0%和77.4%)(P=0.80)。1年VAS和JOA评分组间差异无统计学意义(P值分别为0.82和0.80)。与无反应组相比,反应组注射后1个月VAS评分明显降低(19.7比66.0,ppp)。结论:CIT治疗LLDH的有效率与内侧LDH相当。因此,CIT是治疗LLDH的有效方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Clinical Outcomes of Condoliase Injection Therapy for Lateral Lumbar Disc Herniation.

Clinical Outcomes of Condoliase Injection Therapy for Lateral Lumbar Disc Herniation.

Clinical Outcomes of Condoliase Injection Therapy for Lateral Lumbar Disc Herniation.

Clinical Outcomes of Condoliase Injection Therapy for Lateral Lumbar Disc Herniation.

Introduction: This study aimed to evaluate the efficacy of condoliase injection therapy (CIT) for lateral lumbar disc herniation (LLDH).

Methods: This retrospective study included 157 of 180 enrolled patients (70 males, 87 females; mean age: 52.6±16.9 years). These patients were divided into two groups (group L: LLDH, group M: medial LDH [subligamentous and transligamentous]). From baseline to 1 year after injection (final follow-up), leg pain was assessed using the visual analog scale (VAS) and the Japanese Orthopedic Association (JOA) scoring for CIT's clinical efficacy of CIT. Radiography and magnetic resonance imaging conducted before and 3 months after the injection were assessed. Patients with a VAS improvement of ≥50% at the final follow-up were defined as responders. The responder and nonresponder LLDH groups were also compared.

Results: Groups L and M showed comparable responder rates (75.0% and 77.4%, respectively) (P=0.80). VAS and JOA scores at 1 year showed no significant differences between the groups (P=0.82 and 0.80, respectively). VAS score at 1 month after injection reduced considerably in the responder group compared with that in the nonresponder group (19.7 vs. 66.0, P<0.01) and continued to decrease at the last follow-up (3.5 vs. 52.0, P<0.001). Nonresponders had significantly lower disc heights after 3 months. However, intervertebral instability, alignment, and disc degeneration did not differ between the responders and nonresponders.

Conclusions: The response rate of CIT for LLDH was comparable to that for medial LDH. Therefore, CIT is an effective treatment for LLDH.

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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
71
审稿时长
15 weeks
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