Edyta Krzych-Fałta, Oksana Wojas, Konrad Furmańczyk, Diana Dziewa-Dawidczyk, Barbara Piekarska, Bolesław Samoliński, Adam Sybilski
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The project was conducted in 8 urban areas (Gdańsk, Wrocław, Poznań, Katowice, Kraków, Lublin, Białystok, Warsaw) and 1 rural area (Krasnystaw county). This study had 2 stages; the first stage involved grouping the 22 500 respondents based on their questionnaire responses with the use of a Personal Digital Assistant (PDA); the second stage involved 7000 subjects, who underwent additional assessments: skin prick tests (birch, grasses/cereals, <i>Dermatophagoides pteronyssinus</i> and <i>Dermatophagoides farinae</i>, molds [set I: <i>Botrytis cinerea</i>, <i>Cladosporium herbarum</i>, <i>Alternaria tenuis</i>, <i>Curvularia lunata</i>, <i>Fusarium moniliforme</i>, <i>Helminthosporium</i>], molds [set II: <i>Aspergillus fumigatus</i>, <i>Mucor mucedo</i>, <i>Penicillium notatum</i>, <i>Pullularia pullulans</i>, <i>Rhizopus nigricans</i>, <i>Serpula lacrymans</i>], cat, dog, molds <i>Cladosporium herbarum</i>, <i>Alternaria tenuis</i>) and spirometry tests.</p><p><strong>Results: </strong>The age at which children attend the nursery school is critical to the development of allergic diseases; in allergic rhinitis, the risk of an IgE-dependent reaction is 2 times higher in the second than in the first year of life (p = 0.00147, p < 0.05), while in asthma, having a large number of siblings increases the risk of developing obstructive disease by almost 6 times (p = 0.00316, p < 0.05).The age at which children attend the nursery school is critical to the development of allergic diseases; in allergic rhinitis, the risk of an IgE-dependent reaction is 2 times higher in the second than in the first year of life (p = 0.00147, p < 0.05), while in asthma, having a large number of siblings increases the risk of developing obstructive disease by almost 6 times (p = 0.00316, p < 0.05).</p><p><strong>Conclusions: </strong>The hygiene theory is particularly applicable and can explain the relationship of selected habits in the development of allergic diseases. Int J Occup Med Environ Health. 2023;36(1):69-83.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5a/f0/ijomeh-36-69.PMC10464791.pdf","citationCount":"0","resultStr":"{\"title\":\"Evaluation of selected aspects of the hygiene hypothesis and their effect on the incidence of allergy.\",\"authors\":\"Edyta Krzych-Fałta, Oksana Wojas, Konrad Furmańczyk, Diana Dziewa-Dawidczyk, Barbara Piekarska, Bolesław Samoliński, Adam Sybilski\",\"doi\":\"10.13075/ijomeh.1896.01880\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>The development of allergic conditions is largely dependent on the interactions between genetic (individual genetic predisposition) and environmental factors (exposure to risk factors). 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引用次数: 0
摘要
目的:过敏性疾病的发展在很大程度上取决于遗传(个体遗传易感性)和环境因素(暴露于危险因素)之间的相互作用。本研究的目的是试图评估卫生理论的选定要素在变应性疾病(如过敏性鼻炎和哮喘)发展中的影响。材料与方法:研究对象为女性5518人,男性3868人。使用的方法是欧洲共同体呼吸健康调查II和国际儿童哮喘和过敏研究问卷,经过验证并适应中欧和东欧的条件。该项目在8个城市地区(Gdańsk、Wrocław、波兹纳瓦、卡托维兹、Kraków、卢布林、Białystok、华沙)和1个农村地区(克拉斯尼斯塔夫县)进行。这项研究分为两个阶段;第一阶段是使用个人数码助理(PDA)对22500名受访者进行分组;第二阶段涉及7000名受试者,他们接受了额外的评估:皮肤点刺试验(桦木、草/谷物、翼状皮蛾和粉状皮蛾)、霉菌[组1:灰葡萄孢菌、草本枝孢菌、线虫菌、弯孢菌、镰孢菌、蠕虫菌]、霉菌[组2:烟曲霉、Mucor mucdo、青霉菌、Pullularia pullulans、Rhizopus nigricans、Serpula crrymans)、猫、狗、霉菌(Cladosporium herbarum、Alternaria tenuis)和肺活量测定试验。结果:儿童上幼儿园的年龄对过敏性疾病的发展至关重要;在变应性鼻炎中,2岁时发生ige依赖性反应的风险是1岁时的2倍(p = 0.00147, p < 0.05),而在哮喘中,兄弟姐妹数量多会使发生阻塞性疾病的风险增加近6倍(p = 0.00316, p < 0.05)。儿童上幼儿园的年龄对过敏性疾病的发展至关重要;在变应性鼻炎中,2岁时发生ige依赖性反应的风险是1岁时的2倍(p = 0.00147, p < 0.05),而在哮喘中,兄弟姐妹数量多会使发生阻塞性疾病的风险增加近6倍(p = 0.00316, p < 0.05)。结论:卫生学理论特别适用,可以解释过敏性疾病发生过程中特定习惯的关系。中华医学杂志,2009;36(1):69-83。
Evaluation of selected aspects of the hygiene hypothesis and their effect on the incidence of allergy.
Objectives: The development of allergic conditions is largely dependent on the interactions between genetic (individual genetic predisposition) and environmental factors (exposure to risk factors). The aim of this study was an attempt to assess the influence of selected elements of the hygiene theory in the development of allergic diseases such as allergic rhinitis and asthma.
Material and methods: The study group consisted of 5518 women and 3868 men. The method that was used was the European Community Respiratory Health Survey II and International Study of Asthma and Allergies in Childhood questionnaire validated and adapted to Central and Eastern European conditions. The project was conducted in 8 urban areas (Gdańsk, Wrocław, Poznań, Katowice, Kraków, Lublin, Białystok, Warsaw) and 1 rural area (Krasnystaw county). This study had 2 stages; the first stage involved grouping the 22 500 respondents based on their questionnaire responses with the use of a Personal Digital Assistant (PDA); the second stage involved 7000 subjects, who underwent additional assessments: skin prick tests (birch, grasses/cereals, Dermatophagoides pteronyssinus and Dermatophagoides farinae, molds [set I: Botrytis cinerea, Cladosporium herbarum, Alternaria tenuis, Curvularia lunata, Fusarium moniliforme, Helminthosporium], molds [set II: Aspergillus fumigatus, Mucor mucedo, Penicillium notatum, Pullularia pullulans, Rhizopus nigricans, Serpula lacrymans], cat, dog, molds Cladosporium herbarum, Alternaria tenuis) and spirometry tests.
Results: The age at which children attend the nursery school is critical to the development of allergic diseases; in allergic rhinitis, the risk of an IgE-dependent reaction is 2 times higher in the second than in the first year of life (p = 0.00147, p < 0.05), while in asthma, having a large number of siblings increases the risk of developing obstructive disease by almost 6 times (p = 0.00316, p < 0.05).The age at which children attend the nursery school is critical to the development of allergic diseases; in allergic rhinitis, the risk of an IgE-dependent reaction is 2 times higher in the second than in the first year of life (p = 0.00147, p < 0.05), while in asthma, having a large number of siblings increases the risk of developing obstructive disease by almost 6 times (p = 0.00316, p < 0.05).
Conclusions: The hygiene theory is particularly applicable and can explain the relationship of selected habits in the development of allergic diseases. Int J Occup Med Environ Health. 2023;36(1):69-83.
期刊介绍:
The Journal is dedicated to present the contemporary research in occupational and environmental health from all over the world. It publishes works concerning: occupational and environmental: medicine, epidemiology, hygiene and toxicology; work physiology and ergonomics, musculoskeletal problems; psychosocial factors at work, work-related mental problems, aging, work ability and return to work; working hours, shift work; reproductive factors and endocrine disruptors; radiation, ionizing and non-ionizing health effects; agricultural hazards; work safety and injury and occupational health service; climate change and its effects on health; omics, genetics and epigenetics in occupational and environmental health; health effects of exposure to nanoparticles and nanotechnology products; human biomarkers in occupational and environmental health, intervention studies, clinical sciences’ achievements with potential to improve occupational and environmental health.