Matthew M. Crane , Mitsuhiro Tsuchiya , Ben W. Blue , Jared D. Almazan , Kenneth L. Chen , Siobhan R. Duffy , Alexandra Golubeva , Annaiz M. Grimm , Alison M. Guard , Shauna A. Hill , Ellen Huynh , Ryan M. Kelly , Michael Kiflezghi , Hyunsung D. Kim , Mitchell Lee , Ting-I. Lee , Jiayi Li , Bao M.G. Nguyen , Riley M. Whalen , Feng Y. Yeh , Matt Kaeberlein
{"title":"Rb类似物wh5调节出芽酵母G1向S的转变和细胞大小，但不调节复制寿命","authors":"Matthew M. Crane , Mitsuhiro Tsuchiya , Ben W. Blue , Jared D. Almazan , Kenneth L. Chen , Siobhan R. Duffy , Alexandra Golubeva , Annaiz M. Grimm , Alison M. Guard , Shauna A. Hill , Ellen Huynh , Ryan M. Kelly , Michael Kiflezghi , Hyunsung D. Kim , Mitchell Lee , Ting-I. Lee , Jiayi Li , Bao M.G. Nguyen , Riley M. Whalen , Feng Y. Yeh , Matt Kaeberlein","doi":"10.1016/j.tma.2019.10.002","DOIUrl":null,"url":null,"abstract":"<div><p>An increase in cell size with age is a characteristic feature of replicative aging in budding yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced cell size, and has been previously suggested to increase replicative lifespan. Upon careful analysis of multiple independently derived haploid and homozygous diploid <em>whi5Δ</em> mutants, we find no effect on lifespan, but we do confirm the reduction in cell size. We suggest that instead of antagonizing lifespan, the elongated G1 phase of the cell cycle during aging may actually play an important role in allowing aged cells time to repair accumulating DNA damage.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"3 ","pages":"Pages 104-108"},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2019.10.002","citationCount":"4","resultStr":"{\"title\":\"Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast\",\"authors\":\"Matthew M. Crane , Mitsuhiro Tsuchiya , Ben W. Blue , Jared D. Almazan , Kenneth L. Chen , Siobhan R. Duffy , Alexandra Golubeva , Annaiz M. Grimm , Alison M. Guard , Shauna A. Hill , Ellen Huynh , Ryan M. Kelly , Michael Kiflezghi , Hyunsung D. Kim , Mitchell Lee , Ting-I. Lee , Jiayi Li , Bao M.G. Nguyen , Riley M. Whalen , Feng Y. Yeh , Matt Kaeberlein\",\"doi\":\"10.1016/j.tma.2019.10.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>An increase in cell size with age is a characteristic feature of replicative aging in budding yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced cell size, and has been previously suggested to increase replicative lifespan. Upon careful analysis of multiple independently derived haploid and homozygous diploid <em>whi5Δ</em> mutants, we find no effect on lifespan, but we do confirm the reduction in cell size. We suggest that instead of antagonizing lifespan, the elongated G1 phase of the cell cycle during aging may actually play an important role in allowing aged cells time to repair accumulating DNA damage.</p></div>\",\"PeriodicalId\":36555,\"journal\":{\"name\":\"Translational Medicine of Aging\",\"volume\":\"3 \",\"pages\":\"Pages 104-108\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.tma.2019.10.002\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational Medicine of Aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468501119300380\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Medicine of Aging","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468501119300380","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast
An increase in cell size with age is a characteristic feature of replicative aging in budding yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced cell size, and has been previously suggested to increase replicative lifespan. Upon careful analysis of multiple independently derived haploid and homozygous diploid whi5Δ mutants, we find no effect on lifespan, but we do confirm the reduction in cell size. We suggest that instead of antagonizing lifespan, the elongated G1 phase of the cell cycle during aging may actually play an important role in allowing aged cells time to repair accumulating DNA damage.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
