睡眠片段对脑小血管疾病大鼠模型白质病理学的影响

IF 5.3 2区医学 Q1 CLINICAL NEUROLOGY

Sleep Pub Date : 2024-04-12 DOI:10.1093/sleep/zsad225

Xiang Fu, Xiao-Jie Wan, Jun-Yi Liu, Qian Sun, Yun Shen, Jie Li, Cheng-Jie Mao, Quan-Hong Ma, Fen Wang, Chun-Feng Liu

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引用次数: 0

摘要

研究目的：越来越多的证据表明睡眠与脑小血管疾病（CSVD）之间存在关联。然而，人们对睡眠质量差与脑白质损伤（CSVD的典型特征）之间的确切因果关系及其内在机制知之甚少：方法：对自发性高血压大鼠（SHR）和对照组 Wistar Kyoto 大鼠进行为期 16 周的睡眠中断试验。观察慢性睡眠中断对深部白质和认知能力的影响：结果：SHR 被确认为 CSVD 的大鼠模型。睡眠片段诱导了应变依赖性白质异常，其特征是髓鞘完整性降低、少突胶质前体细胞（OPC）成熟受损和促炎性小胶质细胞极化。在睡眠恢复后，可同时观察到OPC和小胶质细胞的部分可逆表型：结论：在 CSVD 大鼠模型中，长期 SF 会对深部白质产生病理影响。促炎性小胶质细胞活化和 OPC 成熟受阻可能与睡眠和白质损伤的关联机制有关。

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Effects of sleep fragmentation on white matter pathology in a rat model of cerebral small vessel disease.

Study objectives: Mounting evidence indicated the correlation between sleep and cerebral small vessel disease (CSVD). However, little is known about the exact causality between poor sleep and white matter injury, a typical signature of CSVD, as well as the underlying mechanisms.

Methods: Spontaneously hypertensive rats (SHR) and control Wistar Kyoto rats were subjected to sleep fragmentation (SF) for 16 weeks. The effects of chronic sleep disruption on the deep white matter and cognitive performance were observed.

Results: SHR were validated as a rat model for CSVD. Fragmented sleep induced strain-dependent white matter abnormalities, characterized by reduced myelin integrity, impaired oligodendrocytes precursor cells (OPC) maturation and pro-inflammatory microglial polarization. Partially reversible phenotypes of OPC and microglia were observed in parallel following sleep recovery.

Conclusions: Long-term SF-induced pathological effects on the deep white matter in a rat model of CSVD. The pro-inflammatory microglial activation and the block of OPC maturation may be involved in the mechanisms linking sleep to white matter injury.

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来源期刊

Sleep 医学-临床神经学

CiteScore

10.10

自引率

10.70%

发文量

1134

审稿时长

3 months

期刊介绍： SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.