埃塞俄比亚南部Wolaita Sodo大学综合专科医院接受抗逆转录病毒治疗的成年人类免疫病毒感染患者死亡率及其预测因素:一项回顾性随访研究

IF 1.5 Q4 INFECTIOUS DISEASES
Tagese Yakob Barata, Girumneh Abiso, Eskinder Israel, Simegn Molla, Eskinder Wolka
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引用次数: 0

摘要

背景:尽管抗逆转录病毒治疗的目标是改善健康状况,延长艾滋病毒感染者的生命,减少艾滋病毒相关死亡,但使用抗逆转录病毒治疗仍会导致艾滋病毒相关死亡率的持续上升。本研究旨在评估埃塞俄比亚南部Wolaita Sodo综合专科医院接受抗逆转录病毒治疗随访的成年艾滋病毒/艾滋病患者的死亡率及其预测因素。方法:于2021年5月1日至6月30日对该院成年HIV/AIDS患者进行回顾性随访研究,共纳入441例成年HIV/AIDS患者。拟合Kaplan-Meier失效曲线和Log rank检验,并采用cox比例风险模型确定死亡率的预测因子。计算粗风险比(AHR)和校正风险比(AHR)及其95%置信区间(CI)以显示关联强度。使用基于舍恩菲尔德残差的全局检验来进行比例假设。结果:每100人年观察的死亡率为5.61 (95% CI, 4.2-7.3)。在多变量分析中,HIV/AIDS患者丧偶(aHR;10.9 (95% CI, 3.13-37.99),药物粘附不良(aHR;5.6 (95% CI, 2.4-13.2)和公平粘附(aHR;3.53 (95% CI, 1.58-7.87), WHO临床IV期(aHR;5.91, (95% CI, 1.41-24.71),药物使用史(aHR;2.02 (95% CI, 1.01-4.06)和静脉用药史(aHR;2.26 (95% CI, 1.10-4.74)独立预测患者死亡率。结论:本组患者死亡率较高。通过特别关注丧偶、基线时药物使用、晚期临床IV期、基线时静脉注射药物使用史以及有依从性问题的个体,可以将死亡率降至最低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Incidence of Mortality and Its Predictors Among Adult Human Immune Virus Infected Patients on Antiretroviral Therapy in Wolaita Sodo University Comprehensive Specialized Hospital, Southern Ethiopia: A Retrospective Follow-Up Study.

Incidence of Mortality and Its Predictors Among Adult Human Immune Virus Infected Patients on Antiretroviral Therapy in Wolaita Sodo University Comprehensive Specialized Hospital, Southern Ethiopia: A Retrospective Follow-Up Study.

Incidence of Mortality and Its Predictors Among Adult Human Immune Virus Infected Patients on Antiretroviral Therapy in Wolaita Sodo University Comprehensive Specialized Hospital, Southern Ethiopia: A Retrospective Follow-Up Study.

Incidence of Mortality and Its Predictors Among Adult Human Immune Virus Infected Patients on Antiretroviral Therapy in Wolaita Sodo University Comprehensive Specialized Hospital, Southern Ethiopia: A Retrospective Follow-Up Study.

Background: Although the goal of ART is to have better health, extend the life of the HIV-infected patient, and decrease HIV-related death, there is a continuation of HIV-related mortality with the use of ART. This study aimed to assess the incidence of mortality and its predictors among adult HIV/AIDS patients who were on ART follow-up at Wolaita Sodo Comprehensive specialized hospital in southern Ethiopia.

Methods: A retrospective follow-up study was conducted from May 1 to June 30, 2021 among adult HIV/AIDS patients with a total of 441 adult HIV/AIDS patients in this hospital included. Kaplan-Meier failure curve and Log rank test were fitted, and Cox-proportional hazards model was also used to identify the predictors of mortality. Both crude and adjusted hazard ratios (AHR) with their 95% confidence interval (CI) were calculated to show the strength of association. The proportional assumption was conducted by using a global test based on the Schoenfeld residuals.

Results: Incidence of the mortality rate was 5.61 (95% CI, 4.2-7.3) per 100 person-years observation. In the multivariable analysis, HIV/AIDS patients were widowed (aHR; 10.9 (95% CI, 3.13-37.99), poorly drug-adhered (aHR; 5.6 (95% CI, 2.4-13.2) and fair adhered (aHR; 3.53 (95% CI, 1.58-7.87), WHO clinical stage IV (aHR; 5.91, (95% CI, 1.41-24.71), history of substance use (aHR; 2.02 (95% CI, 1.01-4.06) and history of IV drug use (aHR; 2.26 (95% CI, 1.10-4.74) independently predicted the mortality of patients.

Conclusion: In this study, incidence of mortality was relatively high. The rate of mortality may be minimized by paying particular attention to individuals with widowing, substance use at the baseline, advanced clinical stage IV, history of IV drug use at the baseline, and those with adherence problems.

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来源期刊
CiteScore
3.00
自引率
6.70%
发文量
61
审稿时长
16 weeks
期刊介绍: About Dove Medical Press Dove Medical Press Ltd is part of Taylor & Francis Group, the Academic Publishing Division of Informa PLC. We specialize in the publication of Open Access peer-reviewed journals across the broad spectrum of science, technology and especially medicine. Dove Medical Press was founded in 2003 with the objective of combining the highest editorial standards with the ''best of breed'' new publishing technologies. We have offices in Manchester and London in the United Kingdom, representatives in Princeton, New Jersey in the United States, and our editorial offices are in Auckland, New Zealand. Dr Scott Fraser is our Medical Director based in the UK. He has been in full time clinical practice for over 20 years as well as having an active research interest.
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