墨西哥肠炎沙门氏菌MLST群体结构和耐药基因的基因组分析。

IF 2.3 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Genome Pub Date : 2023-12-01 Epub Date: 2023-07-21 DOI:10.1139/gen-2023-0007
Adrián Gómez-Baltazar, Angélica Godínez-Oviedo, Gerardo Vázquez-Marrufo, Ma Soledad Vázquez-Garcidueñas, Montserrat Hernández-Iturriaga
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引用次数: 0

摘要

肠炎沙门氏菌是世界范围内公共卫生机构报告的最常见的食源性病原体之一。本研究对墨西哥产肠炎沙门氏菌(n = 2561)的多位点序列分型(MLST)种群结构和AMR基因频率进行了分析。最常见的分离源为食物(44.28%)、环境(27.41%)、动物相关(24.83%)和人类(3.48%)。最常见的血清型为Newport(8.51%)、Oranienburg(7.03%)、Anatum(5.78%)、Typhimurium(5.12%)和Infantis(4.57%)。通过7基因MLST方案确定,最常见的序列类型是ST23、ST64和ST32。核心基因组MLST方案鉴定出132个HC2000和195个HC900分层聚类,其中HC2000_2聚类在墨西哥最普遍(n = 256)。在638个肠链球菌基因组序列中共检测到13个抗菌类78个不同的AMR基因。使用频率最高的是氨基糖苷类(31.76%),其次是四环素类(12.53%)和磺胺类(11.91%)。这些结果可以帮助墨西哥的公共卫生机构优先考虑他们的努力和资源,以增加传播沙门氏菌菌株的基因组测序。此外,它们为地方和全球公共卫生工作提供了宝贵的信息,以减少食源性疾病和抗生素耐药性的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genomic analysis of the MLST population structure and antimicrobial resistance genes associated with Salmonella enterica in Mexico.

Salmonella enterica is one of the most commonly reported foodborne pathogens by public health agencies worldwide. In this study, the multilocus sequence typing (MLST) population structure and frequency of antimicrobial resistance (AMR) genes were evaluated in S. enterica strains from Mexico (n = 2561). The most common sources of isolation were food (44.28%), environment (27.41%), animal-related (24.83%), and human (3.48%). The most prevalent serovars were Newport (8.51%), Oranienburg (7.03%), Anatum (5.78%), Typhimurium (5.12%), and Infantis (4.57%). As determined by the 7-gene MLST scheme, the most frequent sequence types were ST23, ST64, and ST32. The core genome MLST scheme identified 132 HC2000 and 195 HC900 hierarchical clusters, with the HC2000_2 cluster being the most prevalent in Mexico (n = 256). A total of 78 different AMR genes belonging to 13 antimicrobial classes were detected in 638 genomic assemblies of S. enterica. The most frequent class was aminoglycosides (31.76%), followed by tetracyclines (12.53%) and sulfonamides (11.91%). These results can help public health agencies in Mexico prioritize their efforts and resources to increase the genomic sequencing of circulating Salmonella strains. Additionally, they provide valuable information for local and global public health efforts to reduce the impact of foodborne diseases and AMR.

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来源期刊
Genome
Genome 生物-生物工程与应用微生物
CiteScore
5.30
自引率
3.20%
发文量
42
审稿时长
6-12 weeks
期刊介绍: Genome is a monthly journal, established in 1959, that publishes original research articles, reviews, mini-reviews, current opinions, and commentaries. Areas of interest include general genetics and genomics, cytogenetics, molecular and evolutionary genetics, developmental genetics, population genetics, phylogenomics, molecular identification, as well as emerging areas such as ecological, comparative, and functional genomics.
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