放射治疗中的缺氧靶向剂量涂画

IF 2.6 3区 医学 Q3 ONCOLOGY
Ahmed Salem
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引用次数: 3

摘要

缺氧(缺氧)发生在大多数实体恶性肿瘤中,尽管具有相当大的异质性。缺氧通过促进基因组不稳定性、逃避包括放疗在内的抗癌治疗和增加转移风险,与侵袭性癌症表型相关。因此,缺氧会导致癌症结果不佳。靶向低氧改善癌症的结果是一个有吸引力的治疗策略。缺氧靶向剂量绘制将放疗剂量升级为缺氧亚体积,如使用缺氧成像进行量化和空间映射所示。这种治疗方法可以在不需要缺氧靶向药物的情况下克服缺氧诱导的放射抵抗并改善患者的预后。本文将回顾个性化低氧靶向剂量绘画的前提和基础证据。它将提供有关缺氧成像生物标志物的数据,强调这种方法的挑战和潜在好处,并为该领域未来的研究重点提供建议。基于缺氧的个性化放疗降级策略也将得到解决。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hypoxia-Targeted Dose Painting in Radiotherapy

Hypoxia (oxygen deprivation) occurs in most solid malignancies, albeit with considerable heterogeneity. Hypoxia is associated with an aggressive cancer phenotype by promotion of genomic instability, evasion of anti-cancer therapies including radiotherapy and enhancement of metastatic risk. Therefore, hypoxia results in poor cancer outcomes. Targeting hypoxia to improve cancer outcomes is an attractive therapeutic strategy. Hypoxia-targeted dose painting escalates radiotherapy dose to hypoxic sub-volumes, as quantified and spatially mapped using hypoxia imaging. This therapeutic approach could overcome hypoxia-induced radioresistance and improve patient outcomes without the need for hypoxia-targeted drugs. This article will review the premise and underpinning evidence for personalized hypoxia-targeted dose painting. It will present data on relevant hypoxia imaging biomarkers, highlight the challenges and potential benefit of this approach and provide recommendations for future research priorities in this field. Personalized hypoxia-based radiotherapy de-escalation strategies will also be addressed.

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来源期刊
CiteScore
5.80
自引率
0.00%
发文量
48
审稿时长
>12 weeks
期刊介绍: Each issue of Seminars in Radiation Oncology is compiled by a guest editor to address a specific topic in the specialty, presenting definitive information on areas of rapid change and development. A significant number of articles report new scientific information. Topics covered include tumor biology, diagnosis, medical and surgical management of the patient, and new technologies.
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