在猕猴繁殖群中排除水平和垂直传播作为克氏锥虫感染的主要来源。

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES
Comparative medicine Pub Date : 2023-06-01 Epub Date: 2023-06-02 DOI:10.30802/AALAS-CM-23-000005
Whitney M Kiehl, Carolyn L Hodo, Gabriel L Hamer, Sarah A Hamer, Gregory K Wilkerson
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引用次数: 0

摘要

克氏锥虫是媒介传播的原生动物寄生虫,可在人类和动物中引起恰加斯病。这种寄生虫是美国南部的地方病,在那里,生物医学设施的室外NHP有感染的风险。除了克氏锥虫引起的直接发病外,受感染动物的生物医学研究用途有限,因为即使在没有临床疾病的动物中,感染也会产生混淆的病理生理变化。部分由于担心克氏弓形虫在动物之间的直接传播,一些机构已扑杀、移除或以其他方式将受感染的NHP与未感染的动物种群隔离开来。然而,在美国,没有记录圈养型NHP水平或垂直传播的数据。为了评估动物间传播的可能性,并确定影响NHPs新感染分布的环境因素,我们对德克萨斯州南部一个恒河猴(Macaca mulatta)繁殖群体进行了回顾性流行病学研究。我们利用存档的生物样本和饲养记录来确定猕猴血清转换的时间和地点。这些数据用于对地理位置和动物关联如何影响疾病传播进行空间分析,并推断水平或垂直传播途径的重要性。大多数克氏体感染呈空间聚集性,表明环境因素促进了该设施不同区域的媒介暴露。虽然我们不能排除水平传播,但我们的数据表明水平传播不是疾病传播的关键途径。垂直传播不是这个群体的一个促成因素。综上所述,我们的研究结果表明,本地triatome媒介是我们殖民地圈养猕猴感染T. cruzi的主要来源。因此,限制与病媒的接触,而不是隔离受感染的猕猴,是美国南部户外猕猴收容机构预防疾病的关键策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exclusion of Horizontal and Vertical Transmission as Major Sources of Trypanosoma Cruzi Infections in a Breeding Colony of Rhesus Macaques (Macaca Mulatta).

The vector-borne protozoal parasite Trypanosoma cruzi causes Chagas disease in humans and animals. This parasite is endemic to the southern United States where outdoor-housed NHP at biomedical facilities are at risk of infection. In addi- tion to the direct morbidity caused by T. cruzi, infected animals are of limited biomedical research use because infections can produce confounding pathophysiologic changes even in animals with no clinical disease. In part due to concerns for direct T. cruzi transmission between animals, infected NHP at some institutions have been culled, removed, or otherwise isolated from uninfected animal populations. However, data that document horizontal or vertical transmission in captive NHP in the United States are not available. To evaluate the potential for inter-animal transmission and to identify environmental factors that affect the distribution of new infections in NHPs, we conducted a retrospective epidemiologic study of a rhesus macaque ( Macaca mulatta ) breeding colony in south Texas. We used archived biologic samples and husbandry records to identify the time and location of macaque seroconversion. These data were used to perform a spatial analysis of how geographic location and animal associations affected the spread of disease and to infer the importance of horizontal or vertical routes of transmission. The majority of T. cruzi infections were spatially clustered, suggesting that environmental factors promoted vector exposure in various areas of the facility. Although we cannot not rule out horizontal transmission, our data suggest that horizontal transmission was not a critical route for spread for the disease. Vertical transmission was not a contributing factor in this colony. In conclusion, our findings suggest that local triatome vectors were the major source of T. cruzi infections in captive macaques in our colony. Therefore, limiting contact with vectors, rather than segregation of infected macaques, is a key strategy for disease prevention at institutions that house macaques outdoors in the southern United States.

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来源期刊
Comparative medicine
Comparative medicine 医学-动物学
CiteScore
1.90
自引率
0.00%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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