烟酸药物剂量对亚急性糖皮质激素诱导的大鼠睾丸损伤的影响。

IF 2.9 4区 医学 Q2 PHARMACOLOGY & PHARMACY
E Azimi Zangabad, Tahoora Shomali, L Roshangar
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引用次数: 0

摘要

糖皮质激素过量会对男性生殖产生不利影响。本研究评估了药物剂量烟酸对地塞米松治疗大鼠睾丸结构和功能的影响。成年大鼠(48只)随机分为6组:(1)阴性对照组(NC):正常大鼠;(2) 阳性对照(PC):地塞米松7 mg/kg/天,腹膜内注射7次 天;第3-6组(N50、N100、N200和N400):地塞米松和烟酸联合治疗50、100、200和400 mg/kg/天。PC大鼠睾丸重量和体积显著低于NC组(p
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effects of pharmacological doses of niacin on subacute glucocorticoid-induced testicular damage in rats.

Effects of pharmacological doses of niacin on subacute glucocorticoid-induced testicular damage in rats.

Effects of pharmacological doses of niacin on subacute glucocorticoid-induced testicular damage in rats.

Effects of pharmacological doses of niacin on subacute glucocorticoid-induced testicular damage in rats.

Glucocorticoid excess adversely affects male reproduction. This study evaluates effects of pharmacological doses of niacin on testicular structure and function in dexamethasone-treated rats. Adult rats (48) were randomly assigned to 6 equal groups: (1) Negative control (NC): normal rats; (2) Positive control (PC): dexamethasone at 7 mg/kg/day by intraperitoneal injections for 7 days; groups 3-6 (N50, N100, N200, and N400): dexamethasone and concomitant treatment with niacin at 50, 100, 200, and 400 mg/kg/day by oral gavages. Testicular weight and volume of PC rats were significantly lower than the NC group (p < .05). Testicular volume of rats in the N50 and N200 groups was statistically similar to the NC group. Significant decreases in serum testosterone with a slight LH increase were detected in the PC group. Nacin at 50 mg/kg reversed serum testosterone to NC levels and increased serum LH concentration. Niacin only slightly increased epididymal spermatozoa number while all groups of niacin-treated rats had significantly higher percentages of motile spermatozoa compared with the PC group. Hypospermatogenesis, germ cell degeneration and depletion, epithelial vacuolization, and degenerated Leydig cells were observed in PC rats. Lesions were relatively milder in niacin-treated rats. Johnsen scores were also significantly higher in niacin-treated rats. Niacin reduced apoptosis as shown by TUNEL assay. In conclusion, niacin administration at pharmacological doses dose-dependently ameliorates the destructive effects of dexamethasone on sperm motility, Johnsen score, and testicular cell apoptosis in rats with the latter can be considered a decisive mechanism for its positive effects on testis.

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来源期刊
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics
CiteScore
5.30
自引率
3.80%
发文量
120
审稿时长
20 weeks
期刊介绍: PR&P is jointly published by the American Society for Pharmacology and Experimental Therapeutics (ASPET), the British Pharmacological Society (BPS), and Wiley. PR&P is a bi-monthly open access journal that publishes a range of article types, including: target validation (preclinical papers that show a hypothesis is incorrect or papers on drugs that have failed in early clinical development); drug discovery reviews (strategy, hypotheses, and data resulting in a successful therapeutic drug); frontiers in translational medicine (drug and target validation for an unmet therapeutic need); pharmacological hypotheses (reviews that are oriented to inform a novel hypothesis); and replication studies (work that refutes key findings [failed replication] and work that validates key findings). PR&P publishes papers submitted directly to the journal and those referred from the journals of ASPET and the BPS
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