对结肠癌患者E2F转录因子相关的七个特征预后模型的新研究

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Xiaoyong Shen, Zheng Su, Yan Dou, Xin Song
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引用次数: 0

摘要

结肠癌是一种常见的胃肠道肿瘤,其发病机制涉及复杂的因素,尤其是一系列细胞周期相关基因。细胞周期中的E2F转录因子在结肠癌的发生中起着至关重要的作用。建立一种有效的以细胞e2f相关基因为靶点的结肠癌预后模型具有重要意义。这在以前没有报道过。作者首先通过整合TCGA-COAD (n = 521)、GSE17536 (n = 177)和GSE39582 (n = 585)队列的数据,探索E2F基因与结肠癌患者临床结局的联系。使用Cox回归和Lasso建模方法来确定涉及多个中心基因(CDKN2A, GSPT1, PNN, POLD3, PPP1R8, PTTG1和RFC1)的新型结肠癌预后模型。此外,还创建了一个e2f相关的nomogram,可以有效地预测结肠癌患者的生存率。此外,作者首先确定了两个E2F肿瘤簇,它们表现出不同的预后特征。有趣的是,基于e2f的分类和多器官的“蛋白质分泌”问题与“t细胞调节(Tregs)”和“CD56dim自然杀伤细胞”的肿瘤浸润之间的潜在联系被检测到。作者的发现对结肠癌的预后评估和机制探索具有潜在的临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A novel investigation into an E2F transcription factor-related prognostic model with seven signatures for colon cancer patients

A novel investigation into an E2F transcription factor-related prognostic model with seven signatures for colon cancer patients

The pathogenesis of colon cancer, a common gastrointestinal tumour, involves complicated factors, especially a series of cell cycle-related genes. E2F transcription factors during the cell cycle play an essential role in the occurrence of colon cancer. It is meaningful to establish an efficient prognostic model of colon cancer targeting cellular E2F-associated genes. This has not been reported previously. The authors first aimed to explore the links of E2F genes with the clinical outcomes of colon cancer patients by integrating data from the TCGA-COAD (n = 521), GSE17536 (n = 177) and GSE39582 (n = 585) cohorts. The Cox regression and Lasso modelling approach to identify a novel colon cancer prognostic model involving several hub genes (CDKN2A, GSPT1, PNN, POLD3, PPP1R8, PTTG1 and RFC1) were utilised. Moreover, an E2F-related nomogram that efficiently predicted the survival rates of colon cancer patients was created. Additionally, the authors first identified two E2F tumour clusters, which showed distinct prognostic features. Interestingly, the potential links of E2F-based classification and ‘protein secretion’ issues of multiorgans and tumour infiltration of ‘T-cell regulatory (Tregs)’ and ‘CD56dim natural killer cell’ were detected. The authors’ findings are of potential clinical significance for the prognosis assessment and mechanistic exploration of colon cancer.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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