Reply to the Commentary on "Integrated ultrasound protocol in predicting weaning success and extubation failure: a prospective observational study".

Dear Editor, We would like to thank Blanco et al. [1] for their comments on our study. In our study protocol, we measured the lung ultrasound score (LUS) before and after the performance of spontaneous breathing test (SBT). However, we measured the diaphragmatic thickness fraction (DTF) and velocity time integral (VTI) change to passive leg raising (PLR) after SBT only. We are unsure whether measuring them twice at the beginning and end of an SBT would help us to predict weaning failure more reliably. It has been considered that diaphragmatic dysfunction is unlikely to manifest in the short duration of SBT due to accessory muscles compensating for diaphragmatic weakness in the initial period [2]. However, it would be interesting to see how VTI changes to a PLR manoeuvre would change after an SBT. We chose to study the VTI response to PLR given its ease of bedside measurement and its ability to predict preload responsiveness, which has been found to mimic the workload imposed by increased venous return during spontaneous breathing. During a passive leg raise, an increase in venous return is caused by the translocation of blood from the legs and splanchnic circulation towards the heart. This leads to a sequential increase in preload of the right followed by the left ventricle. A normally functioning RV would respond to this increase in preload with an increase in stroke volume, which would lead to an increased preload of the left DOI: https://doi.org/10.5114/ait.2023.129317