Gábor Nagy, Markus Hanner, Benjamin Wizel, Eszter Nagy
{"title":"IC31®辅助IpaD粘膜免疫对志贺菌病小鼠模型的保护作用","authors":"Gábor Nagy, Markus Hanner, Benjamin Wizel, Eszter Nagy","doi":"10.1016/j.provac.2011.07.006","DOIUrl":null,"url":null,"abstract":"<div><p>Mucosal immunization with the conserved Shigella protein IpaD formulated with the two-component adjuvant IC31® provided protection in the murine lung model. Neither the recombinant IpaD alone nor IC31® with an irrelevant protein antigen was effective. IpaD-specific serum IgG and IgA levels obtained by IC31®-adjuvantation were comparable to those induced by known mucosal adjuvants.</p></div>","PeriodicalId":89221,"journal":{"name":"Procedia in vaccinology","volume":"4 ","pages":"Pages 36-41"},"PeriodicalIF":0.0000,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.provac.2011.07.006","citationCount":"1","resultStr":"{\"title\":\"Mucosal immunization with IpaD adjuvanted by IC31® elicits protection in a murine model of shigellosis\",\"authors\":\"Gábor Nagy, Markus Hanner, Benjamin Wizel, Eszter Nagy\",\"doi\":\"10.1016/j.provac.2011.07.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Mucosal immunization with the conserved Shigella protein IpaD formulated with the two-component adjuvant IC31® provided protection in the murine lung model. Neither the recombinant IpaD alone nor IC31® with an irrelevant protein antigen was effective. IpaD-specific serum IgG and IgA levels obtained by IC31®-adjuvantation were comparable to those induced by known mucosal adjuvants.</p></div>\",\"PeriodicalId\":89221,\"journal\":{\"name\":\"Procedia in vaccinology\",\"volume\":\"4 \",\"pages\":\"Pages 36-41\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.provac.2011.07.006\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Procedia in vaccinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1877282X11000075\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Procedia in vaccinology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1877282X11000075","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Mucosal immunization with IpaD adjuvanted by IC31® elicits protection in a murine model of shigellosis
Mucosal immunization with the conserved Shigella protein IpaD formulated with the two-component adjuvant IC31® provided protection in the murine lung model. Neither the recombinant IpaD alone nor IC31® with an irrelevant protein antigen was effective. IpaD-specific serum IgG and IgA levels obtained by IC31®-adjuvantation were comparable to those induced by known mucosal adjuvants.
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