探索微生物群与系统性红斑狼疮之间的复杂关系

IF 5.7 2区 医学 Q1 RHEUMATOLOGY
Current Rheumatology Reports Pub Date : 2023-06-01 Epub Date: 2023-04-21 DOI:10.1007/s11926-023-01102-z
Yu Lei, Qianmei Liu, Qilin Li, Cheng Zhao, Ming Zhao, Qianjin Lu
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引用次数: 0

摘要

审查目的:系统性红斑狼疮(SLE)是一种慢性自身免疫性疾病,以各种自身抗体和多器官功能障碍为特征。肠道、皮肤、口腔和其他表面的微生物群失调对系统性红斑狼疮的发病有重要影响。本文总结了相关研究,并为探索系统性红斑狼疮的发病机制和治疗患者提供了新的微生物组相关策略:最近的发现:系统性红斑狼疮患者的多个微生物群紊乱,其中以肠道微生物群(细菌、病毒和真菌)及其代谢产物的研究最为深入。这种菌群失调可通过肠道渗漏、分子模仿和表观遗传调控等机制促进系统性红斑狼疮的进展。尽管对微生物群与系统性红斑狼疮之间关系的研究受到限制,但针对肠道微生物群的特定干预措施,如益生菌、饮食管理和粪便微生物群移植,已成为很有前景的系统性红斑狼疮治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Exploring the Complex Relationship Between Microbiota and Systemic Lupus Erythematosus.

Exploring the Complex Relationship Between Microbiota and Systemic Lupus Erythematosus.

Purpose of review: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by various autoantibodies and multi-organ. Microbiota dysbiosis in the gut, skin, oral, and other surfaces has a significant impact on SLE development. This article summarizes relevant research and provides new microbiome-related strategies for exploring the mechanisms and treating patients with SLE.

Recent findings: SLE patients have disruptions in multiple microbiomes, with the gut microbiota (bacteria, viruses, and fungi) and their metabolites being the most thoroughly researched. This dysbiosis can promote SLE progression through mechanisms such as the leaky gut, molecular mimicry, and epigenetic regulation. Notwithstanding study constraints on the relationship between microbiota and SLE, specific interventions targeting the gut microbiota, such as probiotics, dietary management, and fecal microbiota transplantation, have emerged as promising SLE therapeutics.

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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
41
期刊介绍: This journal aims to review the most important, recently published research in the field of rheumatology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of rheumatologic conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as the many forms of arthritis, osteoporosis and metabolic bone disease, and systemic lupus erythematosus. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.
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