DJ-1通过与Mena相互作用促进细胞迁移，Mena是果蝇的哺乳动物同源物

Q1 Biochemistry, Genetics and Molecular Biology

Advances in biological regulation Pub Date : 2023-05-01 DOI:10.1016/j.jbior.2022.100943

Sanguk Yun , Sun-Shin Cha , Jae Ho Kim

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引用次数: 1

摘要

DJ-1在2003年被鉴定为与早发性帕金森病发病机制有关的蛋白质后，引起了广泛关注。从那时起，研究揭示了DJ-1在活性氧（ROS）控制、转录调控、伴侣功能、生育能力和细胞转化方面的多功能。在此，我们报道了DJ-1在肌动蛋白细胞骨架重排中的一种新功能。DJ-1被鉴定为Enah/VASP家族蛋白Mena的新结合伴侣，并通过Mena依赖性肌动蛋白聚合和丝足形成促进癌症细胞迁移。这些结果提示了DJ-1依赖性癌症细胞侵袭和转移的新分子机制。

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DJ-1 promotes cell migration by interacting with Mena, the mammalian homolog of Drosophila enabled

DJ-1 has gained extensive attention after being identified in 2003 as a protein implicated in the pathogenesis of early-onset Parkinson's disease. Since then, efforts have revealed versatile DJ-1 functions in reactive oxygen species (ROS) control, transcriptional regulation, chaperone function, fertility, and cell transformation. Herein, we report a novel function of DJ-1 in actin cytoskeletal rearrangements. DJ-1 was identified as a new binding partner of Mena, a protein of the Enah/VASP family, and it promoted cancer cell migration by Mena-dependent actin polymerization and filopodia formation. These results suggest a novel molecular mechanism for DJ-1-dependent cancer cell invasion and metastasis.

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来源期刊

Advances in biological regulation Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

8.90

自引率

0.00%

发文量

审稿时长

17 days