被诊断为认知节奏迟缓的儿童/青少年与被诊断为注意力缺陷/多动障碍的儿童/少年的氧化应激、DNA损伤和炎症标志物可能变化的比较。

IF 1.5 4区 医学 Q2 PEDIATRICS
Ali Güven Kılıçoğlu, Telli Zadehgan Afshord, Songul Derin, Erdem Ertas, Pınar Coskun, Selman Aktas, Eray Metin Guler
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引用次数: 0

摘要

背景:关于迟钝认知节奏(SCT)是否与注意力缺陷/多动障碍(ADHD)不同,一直存在争议。尽管已经有许多关于代谢参数与多动症相关的研究,但还没有对SCT患者进行类似的研究。我们调查了SCT和ADHD在这些因素方面是否存在差异。受试者和方法:本研究包括62名年龄在11至18岁之间的参与者,他们被诊断为多动症(33名受试者)和SCT(29名受试人)。所有参与者的父母填写了48项康纳斯父母评定量表(CPRS)和巴克利儿童注意力量表(BCAS),并抽取所有参与者的血液来比较SCT和ADHD组的代谢、氧化应激和抗氧化状态。一位儿童和青少年精神病学家采访了父母和孩子,使用标准诊断程序评估SCT和ADHD的诊断。结果:SCT组和ADHD组在代谢参数方面的比较中,在总氧化剂状态、总抗氧化状态、氧化应激指数、总硫醇、天然硫醇、二硫化物、白细胞介素-1β、IL-6和DNA损伤方面差异有统计学意义(p p > 0.05)。结论:我们的数据表明,这两种疾病可能不同,但我们认为,表明它们差异的数据总体上仍不确定,但这项研究可能是未来研究的潜在途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of Possible Changes in Oxidative Stress, DNA Damage, and Inflammatory Markers in Children/Adolescents Diagnosed with Sluggish Cognitive Tempo and Children/Adolescents Diagnosed with Attention-Deficit/Hyperactivity Disorder.

Background: There has been a debate on whether sluggish cognitive tempo (SCT) differs from attention-deficit/hyperactivity disorder (ADHD). Although there have been many studies on metabolic parameters in relation to ADHD, no similar studies have been conducted on patients with SCT. We investigated whether there are differences between SCT and ADHD in terms of these factors. Subjects and Methods: Sixty-two participants with ages ranging from 11 to 18 who have diagnosis of ADHD (33 subjects) and SCT (29 subjects) were included in this study. The parents of all participants completed the 48-item Conners' Parent Rating Scale (CPRS) and the Barkley Child Attention Scale (BCAS) forms, and all participants' blood was taken to compare metabolic, oxidative stress, and antioxidant status of the SCT and ADHD groups. A child and adolescent psychiatrist interviewed the parents and children to assess the diagnosis of SCT and ADHD using standard diagnostic procedures. Results: In the comparison between the SCT and ADHD groups in terms of metabolic parameters, statistically significant differences were found in terms of total oxidant status, total antioxidant status, Oxidative Stress Index, total thiol, native thiol, disulfide, interleukin (IL)-1β, IL-6, and DNA damage (p < 0.05), but not in terms of tumor necrosis factor-α (p > 0.05). Conclusions: Our data showed that these two disorders may be different, but we believe that the data that indicate their differences remain inconclusive overall, but this study may be a potential pathway for future research.

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来源期刊
CiteScore
3.60
自引率
5.30%
发文量
61
审稿时长
>12 weeks
期刊介绍: Journal of Child and Adolescent Psychopharmacology (JCAP) is the premier peer-reviewed journal covering the clinical aspects of treating this patient population with psychotropic medications including side effects and interactions, standard doses, and research on new and existing medications. The Journal includes information on related areas of medical sciences such as advances in developmental pharmacokinetics, developmental neuroscience, metabolism, nutrition, molecular genetics, and more. Journal of Child and Adolescent Psychopharmacology coverage includes: New drugs and treatment strategies including the use of psycho-stimulants, selective serotonin reuptake inhibitors, mood stabilizers, and atypical antipsychotics New developments in the diagnosis and treatment of ADHD, anxiety disorders, schizophrenia, autism spectrum disorders, bipolar disorder, eating disorders, along with other disorders Reports of common and rare Treatment Emergent Adverse Events (TEAEs) including: hyperprolactinemia, galactorrhea, weight gain/loss, metabolic syndrome, dyslipidemia, switching phenomena, sudden death, and the potential increase of suicide. Outcomes research.
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