年龄相关合并症对艾滋病病毒感染者联合抗逆转录病毒治疗反应的影响,在埃塞俄比亚Jimma医学中心ART诊所:一项基于医院的巢式病例对照研究。

IF 1.5 Q4 INFECTIOUS DISEASES
Abebaw Abie, Mekonnen Damessa
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引用次数: 0

摘要

导言:尽管撒哈拉以南非洲艾滋病毒患者中与年龄相关的合并症患病率很高,但缺乏有关其对艾滋病毒患者治疗结果影响的数据。因此,本研究旨在评估年龄相关合并症对艾滋病毒感染者抗逆转录病毒治疗(ART)反应的影响。方法:对2022年1月3日至6月2日在吉马医疗中心的成年hiv感染者进行了基于医院的巢式病例对照研究。通过对患者的访谈和病历记录资料,并使用社会科学统计软件包(SPSS) v. 23和p进行分析。结果:总体免疫和病毒学失败率分别为13.8%和13.4%。男性[AOR = 3.079,95% CI(1.139-8.327)]、有年龄相关合并症[AOR:10.57,95% CI(2.810-39.779)]、年龄≥50岁[AOR = 2.855, 95% CI(1.023-7.9650)]、饮酒[AOR = 3.648,95% CI(1.118-11.897)]、基线CD4+计数< 200细胞/uL [AOR:3.862, 95% CI(1.109-13.456)]是免疫功能衰竭的独立预测因子;而被酒精(优势比:3.11,95% CI(1.044 - -9.271)],有一个基准CD4 +计数< 200细胞/ uL(优势比:5.11,95% CI(1.547 - -16.892)],药物依从性较低(优势比:5.92,95% CI(1.81 - -19.36)],卧床不起基线功能状态(优势比:3.902,95% CI(1.237 - -12.307)],和缺乏复方磺胺甲恶唑预防(优势比:2.735,95% CI(1.084 - -6.902)]是一个独立的预测病毒学治疗失败,但年龄更小(< 50岁)保护了病毒学失败。结论:在接受HIV治疗的8名患者中,至少有1名患者出现了免疫和/或病毒学失败。与病毒学结果相比,年龄相关的共病慢性非传染性疾病高度影响免疫学结果。卫生保健提供者应注意与年龄相关的合并症,鼓励改变生活方式,并就药物依从性提供咨询,以改善艾滋病毒患者的临床结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Influence of Age-Associated Comorbidities on Responses to Combination Antiretroviral Therapy Among People Living with HIV, at the ART Clinic of Jimma Medical Center, Ethiopia: A Hospital-Based Nested Case-Control Study.

The Influence of Age-Associated Comorbidities on Responses to Combination Antiretroviral Therapy Among People Living with HIV, at the ART Clinic of Jimma Medical Center, Ethiopia: A Hospital-Based Nested Case-Control Study.

The Influence of Age-Associated Comorbidities on Responses to Combination Antiretroviral Therapy Among People Living with HIV, at the ART Clinic of Jimma Medical Center, Ethiopia: A Hospital-Based Nested Case-Control Study.

The Influence of Age-Associated Comorbidities on Responses to Combination Antiretroviral Therapy Among People Living with HIV, at the ART Clinic of Jimma Medical Center, Ethiopia: A Hospital-Based Nested Case-Control Study.

Introduction: Despite the high prevalence of age-associated comorbidities in HIV patients in sub-Saharan Africa, there is a lack of data on their influence on treatment outcomes in HIV patients. Therefore, this study aimed to assess the impact of age-associated comorbidities on responses to antiretroviral therapy (ART) among people living with HIV.

Methods: A hospital-based nested case-control study was conducted among adult HIV-infected patients at the Jimma Medical Center from January 3 to June 2, 2022. Data were recorded by interviewing the patients and their medical chart and analyzed using The Statistical Package for Social Science (SPSS) v. 23, and at p <0.05.

The results: The overall immunological and virologic failure rates were 13.8% and 13.4%, respectively. Being male [AOR = 3.079,95% CI (1.139-8.327)], having age-associated comorbidity [AOR:10.57,95% CI (2.810-39.779)], age ≥ 50 years [AOR = 2.855, 95% CI (1.023-7.9650)], alcohol intake [AOR = 3.648,95% CI (1.118-11.897)], and having a baseline CD4+ count of < 200 cells/uL [AOR:3.862, 95% CI (1.109-13.456) were an independent predictor of immunological failure; Whereas Being alcoholic [AOR:3.11, 95% CI (1.044-9.271)], having a baseline CD4+ count of < 200 cells/uL [AOR:5.11, 95% CI (1.547-16.892)], a low medication adherence [AOR:5.92, 95% CI (1.81-19.36)], bedridden baseline functional status [AOR:3.902, 95% CI (1.237-12.307)], and lack of cotrimoxazole prophylaxis [AOR:2.735,95% CI (1.084-6.902)] were found to be an independent predictor of virologic treatment failure, but being younger (age < 50 years) was protective for virologic failure.

Conclusion: Out of the eight patients who were treated for HIV at least one patient had developed immunological and/or virological failure. Age-associated comorbid chronic non-communicable diseases highly influence immunological outcomes compared with virological outcomes. Health providers should pay attention to age-associated comorbidities, encourage lifestyle modifications, and counsel on medication adherence to improve clinical outcomes in patients with HIV.

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来源期刊
CiteScore
3.00
自引率
6.70%
发文量
61
审稿时长
16 weeks
期刊介绍: About Dove Medical Press Dove Medical Press Ltd is part of Taylor & Francis Group, the Academic Publishing Division of Informa PLC. We specialize in the publication of Open Access peer-reviewed journals across the broad spectrum of science, technology and especially medicine. Dove Medical Press was founded in 2003 with the objective of combining the highest editorial standards with the ''best of breed'' new publishing technologies. We have offices in Manchester and London in the United Kingdom, representatives in Princeton, New Jersey in the United States, and our editorial offices are in Auckland, New Zealand. Dr Scott Fraser is our Medical Director based in the UK. He has been in full time clinical practice for over 20 years as well as having an active research interest.
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