治疗小儿风湿病。

IF 5.7 2区 医学 Q1 RHEUMATOLOGY
Current Rheumatology Reports Pub Date : 2023-11-01 Epub Date: 2023-08-16 DOI:10.1007/s11926-023-01112-x
Silvia Rosina, Ana Isabel Rebollo-Giménez, Alessandro Consolaro, Angelo Ravelli
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引用次数: 0

摘要

综述目的:总结目前在儿童风湿性疾病(PRD)中采用靶向治疗(T2T)策略的证据。最新发现:PRD管理的最新进展显著提高了实现疾病缓解的能力。完全疾病静止被认为是理想的治疗目标,因为它的实现可以减少长期损伤和身体残疾,并优化生活质量。对成人风湿性疾病的研究表明,如果通过根据定量指标频繁调整治疗来完全抑制炎症过程,患者的预后会得到改善。这种方法是T2T概念的基础,已应用于类风湿性关节炎(RA)的战略试验。此外,还针对RA和其他成人风湿性疾病发布了T2T的建议。目前,人们对在PRD中引入T2T越来越感兴趣,并颁布了针对青少年特发性关节炎(JIA)的治疗建议。针对儿童期系统性红斑狼疮也采取了类似的措施。初步的治疗研究已经探索了JIA的T2T设计。T2T策略是一种现代治疗方法,有望改善PRD患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Treat-to-Target in Pediatric Rheumatic Diseases.

Treat-to-Target in Pediatric Rheumatic Diseases.

Purpose of review: To summarize the current evidence on the adoption of the treat-to-target (T2T) strategy in pediatric rheumatic diseases (PRD).

Recent findings: The recent advances in the management of PRD have markedly increased the ability to achieve disease remission. Complete disease quiescence is regarded as the ideal therapeutic goal because its attainment leads to lesser long-term damage and physical disability, and to optimization of quality of life. Studies in adult rheumatic diseases have shown that patient outcomes are improved if complete suppression of the inflammatory process is aimed for by frequent adjustments of therapy according to quantitative indices. This approach, which underlies the T2T concept, has been applied in strategic trials in rheumatoid arthritis (RA). Furthermore, recommendations for the T2T have been issued for RA and other adult rheumatic diseases. There is currently a growing interest for the introduction of T2T in PRD, and recommendations for treating juvenile idiopathic arthritis (JIA) to target were promulgated. A similar initiative has been undertaken for childhood-onset systemic lupus erythematosus. Preliminary therapeutic studies have explored the T2T design in JIA. The T2T strategy is a modern therapeutic approach that holds the promise of improving the outcomes in patients with PRD.

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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
41
期刊介绍: This journal aims to review the most important, recently published research in the field of rheumatology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of rheumatologic conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as the many forms of arthritis, osteoporosis and metabolic bone disease, and systemic lupus erythematosus. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.
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