[小儿急性髓性白血病核孔蛋白98重排融合基因的研究进展]。

Zhonghua er ke za zhi = Chinese journal of pediatrics Pub Date : 2023-06-02 DOI:10.3760/cma.j.cn112140-20220913-00798

Y F Chen, W W Weng, Y M Tang

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[Research progress of nucleoporin 98-rearranged fusion gene in pediatric acute myeloid leukemia].

随着联合化疗以及造血干细胞移植技术的不断完善，儿童急性髓系白血病（AML）的预后有了明显改善。然而核孔蛋白98（NUP98）重排AML作为一组特殊的白血病亚型，预后显著不良，疾病诱导缓解率低，移植相关复发率高，亟待新的诊疗策略。本文对儿童NUP98重排AML的流行病学特征、发病机制、临床以及分子生物学特征进行综述，旨在为NUP98重排AML的诊治提供指导。.

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Zhonghua er ke za zhi = Chinese journal of pediatrics

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