Self-reported sleep in relation to risk of dementia a quarter of a century later at age 90+: The 90+ Study.

IF 2.2 3区 医学 Q3 CLINICAL NEUROLOGY
Behavioral Sleep Medicine Pub Date : 2023-09-03 Epub Date: 2022-11-23 DOI:10.1080/15402002.2022.2148668
Zarui A Melikyan, Claudia H Kawas, Annlia Paganini-Hill, Luohua Jiang, Bryce A Mander, María M Corrada
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引用次数: 0

Abstract

Objective: To examine sex-specific associations of sleep duration and napping self-reported at mean age of 69 years (range: 53-81) with risk of incident dementia 24 years later at age 90 +.

Method: Analytic sample included individuals from a population-based study who reported sleep and napping once in the 1980s and 24 years later (range: 16-38) joined The 90+ Study and were evaluated in-person. Those without dementia at baseline of The 90+ Study were prospectively followed. Hazard ratios [HR] and 95% confidence intervals [CI] of dementia risk were estimated by Cox regression.

Results: Of 574 participants 71% were women, mean age at start of dementia follow-up with The 90+ Study was 93 years (range: 90-102). After 3.3 years (range: 0.4-13.8) of follow-up 47% developed dementia. Higher risk of dementia at age 90+ was seen in women with <6 hours of self-reported sleep per night (adjusted HR = 2.00; 95% CI = 1.15-3.50; p = .01) compared with 8 hours. Lower risk of dementia at 90+ was seen in men with short-to-moderate (<60 minutes) self-reported naps compared with no naps (HR = 0.33; 95% CI = 0.18-0.63; p < .01).

Conclusions: Sleep and nap 24 years earlier are important risk factors for dementia after age 90.

自我报告的睡眠与四分之一世纪后 90+ 岁痴呆症风险的关系:90+ 研究。
目的研究平均年龄为 69 岁(范围:53-81 岁)时自我报告的睡眠时间和午睡与 24 年后 90 岁以上人群罹患痴呆症风险的性别特异性关联:分析样本包括一项基于人口的研究中的个人,他们在 20 世纪 80 年代和 24 年后(范围:16-38)参加了 90+ 研究,并接受了亲自评估。对那些在 90+ 研究基线时没有痴呆症的人进行了前瞻性跟踪调查。通过 Cox 回归估算痴呆症风险的危险比 [HR] 和 95% 置信区间 [CI]:在 574 名参与者中,71% 为女性,开始接受 90+ 研究痴呆症随访时的平均年龄为 93 岁(范围:90-102)。经过 3.3 年(范围:0.4-13.8)的随访,47% 的人患上了痴呆症。与 8 小时相比,女性在 90 岁以上患痴呆症的风险更高(p = .01)。睡眠时间从短到中的男性在 90 岁以上时患痴呆症的风险较低(p 结论:睡眠和午睡对痴呆症的发生非常重要:提前 24 年睡觉和小睡是 90 岁以后痴呆症的重要风险因素。
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来源期刊
Behavioral Sleep Medicine
Behavioral Sleep Medicine CLINICAL NEUROLOGY-PSYCHIATRY
CiteScore
7.20
自引率
3.20%
发文量
49
审稿时长
>12 weeks
期刊介绍: Behavioral Sleep Medicine addresses behavioral dimensions of normal and abnormal sleep mechanisms and the prevention, assessment, and treatment of sleep disorders and associated behavioral and emotional problems. Standards for interventions acceptable to this journal are guided by established principles of behavior change. Intending to serve as the intellectual home for the application of behavioral/cognitive science to the study of normal and disordered sleep, the journal paints a broad stroke across the behavioral sleep medicine landscape. Its content includes scholarly investigation of such areas as normal sleep experience, insomnia, the relation of daytime functioning to sleep, parasomnias, circadian rhythm disorders, treatment adherence, pediatrics, and geriatrics. Multidisciplinary approaches are particularly welcome. The journal’ domain encompasses human basic, applied, and clinical outcome research. Behavioral Sleep Medicine also embraces methodological diversity, spanning innovative case studies, quasi-experimentation, randomized trials, epidemiology, and critical reviews.
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