Impact of the peripheral blood inflammatory indices and modified nomogram-revised risk index on survival of Extranodal Nasal-Type Natural Killer/T-Cell lymphoma.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Qing Hou, He Li, Yu Liang, Ningning Yao, Xin Cao, Jianting Liu, Bochen Sun, Peixin Feng, Wenjuan Zhang, Jianzhong Cao
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引用次数: 0

Abstract

Background: At present, peripheral blood markers are easily accessible information and clinically valuable prognostic indicators in extranodal nasal-type natural killer/T-cell lymphoma (ENKTCL). Nevertheless, the role of its comprehensive score in ENKTCL remains to be determined.

Objective: Therefore, this study aimed to investigate the prognostic effect of the peripheral inflammation score on ENKTCL.

Methods: The retrospective study included 183 patients with ENKTCL. Univariate Cox regression analyses and least absolute shrinkage and selection operator (LASSO) Cox regression were used to construct the inflammation-related prognostic index named Risk. Univariate and multivariate Cox regression analyses and regression adjustment with propensity score matching (PSM) were used to evaluate the prognostic ability of risk. The performance of the modified nomogram-revised risk index (NRI) by integrating risk was evaluated with the area under the time-dependent receiver operating characteristic (ROC) curve (AUC), decision curve analysis (DCA), and integrated Brier score (IBS).

Results: The risk cut-off value, constructed by the lymphocyte count, platelet count, albumin level, LMR, and PNI, was -1.3486. Before PSM, multivariate analysis showed that risk was significantly associated with OS (HR = 2.577, 95% CI = 1.614-4.114, P< 0.001) and PFS (HR = 2.679, 95% CI = 1.744-4.114, P< 0.001). After PSM adjustment, risk was still an independent factor for OS (HR = 2.829, 95% CI = 1.601-5.001, P< 0.001) and PFS (HR = 2.877, 95% CI = 1.735-4.770, P< 0.001). With the NRI, the modified NRI by integrating risk increased the AUC and clinical net benefit and decreased the IBS.

Conclusions: Risk is an easily accessible and inexpensive indicator that may be used as a prognostic marker and could improve NRI predictive power in patients with ENKTCL.

外周血炎症指数和改良提名图-修订风险指数对鼻外型天然杀伤/T细胞淋巴瘤生存率的影响
背景:目前,外周血标志物是鼻外型自然杀伤/T细胞淋巴瘤(ENKTCL)中易于获取的信息和有临床价值的预后指标。然而,其综合评分在ENKTCL中的作用仍有待确定:因此,本研究旨在探讨外周炎症评分对 ENKTCL 的预后影响:这项回顾性研究纳入了183例ENKTCL患者。采用单变量Cox回归分析和最小绝对缩小和选择算子(LASSO)Cox回归构建炎症相关预后指数,命名为风险。采用单变量和多变量 Cox 回归分析以及倾向评分匹配(PSM)回归调整来评估风险的预后能力。通过与时间相关的接收者操作特征曲线(ROC)下面积(AUC)、决策曲线分析(DCA)和综合布赖尔评分(IBS)评估了通过整合风险而修改的提名图-修订版风险指数(NRI)的性能:由淋巴细胞计数、血小板计数、白蛋白水平、LMR 和 PNI 得出的风险临界值为-1.3486。PSM 调整前,多变量分析显示风险与 OS(HR = 2.577,95% CI = 1.614-4.114,P< 0.001)和 PFS(HR = 2.679,95% CI = 1.744-4.114,P< 0.001)显著相关。经 PSM 调整后,风险仍是影响 OS(HR = 2.829,95% CI = 1.601-5.001,P< 0.001)和 PFS(HR = 2.877,95% CI = 1.735-4.770,P< 0.001)的独立因素。与NRI相比,整合风险的修正NRI提高了AUC和临床净获益,降低了IBS:风险是一个容易获得且成本低廉的指标,可用作ENKTCL患者的预后标志物,并能提高NRI的预测能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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