Melanocytic neoplasms in neurofibromatosis type 1: a systematic review.

IF 1.5 4区 医学 Q3 DERMATOLOGY
Melanoma Research Pub Date : 2023-12-01 Epub Date: 2023-08-14 DOI:10.1097/CMR.0000000000000912
Summer N Meyer, Elanee Simmons, Amy C Studer, Katherine A Rauen, Maija Kiuru
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引用次数: 0

Abstract

Neurofibromatosis type 1 ( NF1 ) is commonly mutated in melanoma, yet the risk of melanoma in individuals with NF1 is incompletely understood. We performed a systematic review to investigate the risk and characteristics of melanoma and melanocytic nevi in NF1 individuals. PubMed was searched for articles describing NF1 individuals with melanoma, or melanocytic nevi. Those with cutaneous and ocular melanomas were compared to the general population using Surveillance, Epidemiology, and End Results data. Fifty-three articles describing 188 NF1 patients were included (melanoma n  = 82, melanocytic nevi n  = 93, melanocytic nevi, and melanoma n  = 13). Compared to the general population, NF1 patients with cutaneous melanomas had earlier melanoma diagnoses (49.1 vs. 58.6 years, P = 0.012), thicker tumors (3.7 vs. 1.2 mm, P = 0.006), and more frequent disease-specific deaths (27.3% vs. 8.6%, P = 0.005) with shorter survival (12.9 vs. 34.2 months, P = 0.011). Ocular melanomas made up 15.0% of all melanomas in NF1 patients versus 1.5% in the general population ( P < 0.001). In pooling all population-based studies describing melanoma in NF1 populations, NF1 individuals had 2.55 higher odds of having melanoma compared to the general population. A nevus spilus was commonly reported among NF1 individuals with nevi (44.8%, 39/87). Our findings suggest that NF1 individuals may have a higher risk for developing melanomas and tend to have thicker melanomas and worse survival compared to the general population, highlighting the importance of cutaneous and ophthalmologic surveillance in NF1 patients. Our review also supports the association between NF1 and nevus spilus.

1型神经纤维瘤病中的黑色素细胞肿瘤:一项系统综述。
1型神经纤维瘤病(NF1)在黑色素瘤中常见突变,但NF1患者患黑色素瘤的风险尚不完全清楚。我们进行了一项系统综述,以研究NF1个体中黑色素瘤和黑色素细胞痣的风险和特征。PubMed搜索了描述患有黑色素瘤或黑色素细胞痣的NF1个体的文章。使用监测、流行病学和最终结果数据,将皮肤和眼部黑色素瘤患者与普通人群进行比较。纳入了53篇描述188名NF1患者的文章(黑色素瘤 = 82,黑色素细胞痣 = 93,黑色素细胞痣和黑色素瘤n = 13) 。与普通人群相比,患有皮肤黑色素瘤的NF1患者更早诊断为黑色素瘤(49.1 vs.58.6 年,P=0.012),较厚的肿瘤(3.7对1.2 mm,P=0.006),以及更频繁的疾病特异性死亡(27.3%对8.6%,P=0.005)和更短的生存期(12.9对34.2 月,P=0.011)。在NF1患者中,眼部黑色素瘤占所有黑色素瘤的15.0%,而在普通人群中占1.5%(P<0.001)。在对NF1人群中黑色素瘤进行的所有基于人群的研究中,与普通人群相比,NF1个体患黑色素瘤几率高2.55。痣溢出在患有痣的NF1个体中常见(44.8%,39/87)。我们的研究结果表明,与普通人群相比,NF1个体患黑色素瘤的风险更高,黑色素瘤更厚,存活率更差,这突出了对NF1患者进行皮肤和眼科监测的重要性。我们的综述也支持NF1和溢痣之间的联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Melanoma Research
Melanoma Research 医学-皮肤病学
CiteScore
3.40
自引率
4.50%
发文量
139
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. ​Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.
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