Single-Cell RNA Sequencing for Studying Human Cancers.

IF 7 Q1 MATHEMATICAL & COMPUTATIONAL BIOLOGY
Dvir Aran
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引用次数: 1

Abstract

Since the first publication a decade ago describing the use of single-cell RNA sequencing (scRNA-seq) in the context of cancer, over 200 datasets and thousands of scRNA-seq studies have been published in cancer biology. scRNA-seq technologies have been applied across dozens of cancer types and a diverse array of study designs to improve our understanding of tumor biology, the tumor microenvironment, and therapeutic responses, and scRNA-seq is on the verge of being used to improve decision-making in the clinic. Computational methodologies and analytical pipelines are key in facilitating scRNA-seq research. Numerous computational methods utilizing the most advanced tools in data science have been developed to extract meaningful insights. Here, we review the advancements in cancer biology gained by scRNA-seq and discuss the computational challenges of the technology that are specific to cancer research.

单细胞RNA测序用于研究人类癌症。
自十年前首次发表描述单细胞RNA测序(scRNA-seq)在癌症背景下的使用以来,已经在癌症生物学中发表了200多个数据集和数千个scRNA-seq研究。scRNA-seq技术已应用于数十种癌症类型和多种研究设计,以提高我们对肿瘤生物学、肿瘤微环境和治疗反应的理解,并且scRNA-seq即将用于改善临床决策。计算方法和分析管道是促进scRNA-seq研究的关键。利用数据科学中最先进的工具,已经开发了许多计算方法来提取有意义的见解。在这里,我们回顾了scRNA-seq在癌症生物学方面取得的进展,并讨论了该技术在癌症研究中所面临的计算挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.10
自引率
1.70%
发文量
0
期刊介绍: The Annual Review of Biomedical Data Science provides comprehensive expert reviews in biomedical data science, focusing on advanced methods to store, retrieve, analyze, and organize biomedical data and knowledge. The scope of the journal encompasses informatics, computational, artificial intelligence (AI), and statistical approaches to biomedical data, including the sub-fields of bioinformatics, computational biology, biomedical informatics, clinical and clinical research informatics, biostatistics, and imaging informatics. The mission of the journal is to identify both emerging and established areas of biomedical data science, and the leaders in these fields.
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