PREVALENCE OF SERRATED POLYPS AND THEIR ASSOCIATION WITH SYNCHRONOUS COLORECTAL ADVANCED ADENOMAS.

Q2 Medicine
Gilmara Coelho Meine, Guilherme Becker Sander
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引用次数: 0

Abstract

•This study revealed a similar prevalence of clinically significant serrated polyps and advanced adenomas among patients who underwent colonoscopy. •Multivariate analysis demonstrated an association between clinically significant serrated polyps and synchronous advanced adenomas, though the strength of this association was stronger for proximal advanced adenomas. •Large serrated polyps and sessile serrated adenomas were associated with proximal advanced adenomas. Background - Serrated lesions are the precursors of up to one-third of colorectal cancer (CRC) cases and share molecular and epidemiological features with interval CRC. Previous studies have reported wide variation in serrated polyp prevalence and diverse magnitude of its relationship with synchronous advanced adenomas.Objective - Describe the prevalence of serrated polyps and evaluate their association with synchronous advanced adenomas. Methods - The study is a retrospective analysis of 1208 colonoscopies performed in patients aged 45 to 75, predominantly for CRC screening. Data on the prevalence of serrated polyps subsets and advanced adenomas were collected, and multivariate analysis were performed to identify the association between serrated polyps and synchronous advanced adenomas. Results - The prevalence of clinically significant serrated polyps (CSSP), large serrated polyps (LSP), and sessile serrated adenomas (SSA) were 11.3%, 6%, and 3.7%. CSSP were associated with synchronous advanced adenomas (OR 2.121, 95%CI 1.321-3.406), regardless of proximal (OR 2.966, 95%CI 1.701-5.170) or distal (OR 1.945, 95%CI 1.081-3.499) location, while LSP (OR 2.872, 95%CI 1.425-5.787) and SSA (OR 5.032, 95%CI 2.395-10.576) were associated with proximal advanced adenomas. Conclusion - The prevalence of CSSP and advanced adenomas were alike. CSSP is a risk factor for advanced adenomas, and the strength of this association is stronger for proximal advanced adenomas. LSP and SSA are associated with proximal advanced adenomas.

锯齿状息肉的患病率及其与同期结直肠晚期腺瘤的关系。
•本研究显示,在接受结肠镜检查的患者中,具有临床意义的锯齿状息肉和晚期腺瘤的患病率相似。•多因素分析表明,临床上显著的锯齿状息肉与同期晚期腺瘤之间存在相关性,尽管这种相关性在近端晚期腺瘤中更强。•大型锯齿状息肉和无柄锯齿状腺瘤与近端晚期腺瘤相关。背景-锯齿状病变是多达三分之一的癌症(CRC)病例的前兆,与间隔期CRC具有共同的分子和流行病学特征。先前的研究报道了锯齿状息肉患病率的广泛差异及其与同步性晚期腺瘤关系的不同程度。目的:描述锯齿状息肉的患病率,并评估其与同期晚期腺瘤的关系。方法:该研究是对1208例45至75岁患者进行结肠镜检查的回顾性分析,主要用于CRC筛查。收集锯齿状息肉亚群和晚期腺瘤的患病率数据,并进行多变量分析,以确定锯齿状息肉和同步性晚期腺瘤之间的相关性。结果-具有临床意义的锯齿状息肉(CSSP)、大锯齿形息肉(LSP)和无柄锯齿状腺瘤(SSA)的患病率分别为11.3%、6%和3.7%。无论近端(OR 2.966,95%CI 1.701-5.170)或远端(OR 1.945,95%CI 1.081-3.499)位置如何,CSSP均与同步性晚期腺瘤相关(OR 2.121,95%CI 1.321-3.406),LSP(OR 2.872,95%CI 1.425-5.787)和SSA(OR 5.032,95%CI 2.395-10.576)与近端晚期腺瘤相关。结论:CSSP和晚期腺瘤的患病率相似。CSSP是晚期腺瘤的一个危险因素,而这种相关性在近端晚期腺瘤中更强。LSP和SSA与近端晚期腺瘤相关。
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来源期刊
Arquivos de Gastroenterologia
Arquivos de Gastroenterologia Medicine-Gastroenterology
CiteScore
2.00
自引率
0.00%
发文量
109
审稿时长
9 weeks
期刊介绍: The journal Arquivos de Gastroenterologia (Archives of Gastroenterology), a quarterly journal, is the Official Publication of the Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia IBEPEGE (Brazilian Institute for Studies and Research in Gastroenterology), Colégio Brasileiro de Cirurgia Digestiva - CBCD (Brazilian College of Digestive Surgery) and of the Sociedade Brasileira de Motilidade Digestiva - SBMD (Brazilian Digestive Motility Society). It is dedicated to the publishing of scientific papers by national and foreign researchers who are in agreement with the aim of the journal as well as with its editorial policies.
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