Comparison of Toxoplasmosis in Narcotic Drug-addicted and Healthy Persons in the Southwest of Iran; A Case-control Study.

Q3 Psychology
Maryam Fasihi-Karami, Mehdi Sayyah, Forough Kazemi, Reza Arjmand
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引用次数: 0

Abstract

Introduction: Toxoplasmosis and narcotic drug addiction are endemic in various regions of Iran. These drugs can provide situations for infections by disrupting the immune system. The current case-control study was designed to determine the prevalence of toxoplasmosis in narcotic drugaddicted persons in comparison with healthy subjects using serology and molecular techniques in the southwest of Iran.

Methods: A total of 201 subjects (including 101 individuals with drug addiction and 100 control participants) were randomly selected. Chronic and acute toxoplasmosis was detected using the enzymelinked immunosorbent assay (ELISA) IgG avidity. T. gondii immunoglobulin G (IgG) and immunoglobulin M (IgM) were also determined by the ELISA. Moreover, the presence of T. gondii in blood samples was diagnosed using the nested-polymerase chain reaction (Nested-PCR).

Results: For T. gondii IgG, 17 (17.0%) of 100 and 39 (38.6%) of 101 cases were diagnosed in the control participants and drug-addicted people, respectively [P=0.001, OR=3.071, CI= (1.591-5.929)]. Moreover, 16 (15.8) and 5 (5.0%) cases were positive for the B1 gene in the drug-addicted patients and controls by the nested-PCR technique, respectively [P=0.019, OR=3.576, CI= (1.257-10.179)]. However, no significant differences were found between the opium (n=64) and crystal methamphetamine (n=37) groups in terms of T. gondii IgG and IgM antibodies and the presence of the parasite in the blood (P>0.05).

Conclusion: The present results demonstrated that the outbreak of the infection was more frequent in narcotic drug-addicted persons than the controls using serology and molecular techniques.

伊朗西南地区吸毒成瘾者与健康人群弓形虫病比较病例对照研究。
简介:弓形虫病和毒品成瘾在伊朗各个地区流行。这些药物可以通过破坏免疫系统为感染提供条件。目前的病例对照研究旨在通过血清学和分子技术确定伊朗西南部麻醉药物成瘾者与健康受试者弓形虫病的患病率。方法:随机抽取201名被试,其中吸毒成瘾者101名,对照组100名。采用酶联免疫吸附试验(ELISA)检测慢性和急性弓形虫病。ELISA法测定弓形虫免疫球蛋白G (IgG)和免疫球蛋白M (IgM)。此外,使用巢式聚合酶链反应(巢式pcr)诊断血液样本中是否存在弓形虫。结果:在100例对照和101例吸毒成瘾者中,弓形虫IgG阳性率分别为17例(17.0%)和39例(38.6%)[P=0.001, OR=3.071, CI=(1.591-5.929)]。巢式pcr检测结果显示,吸毒患者B1基因阳性16例(15.8%),对照组B1基因阳性5例(5.0%)[P=0.019, OR=3.576, CI=(1.257 ~ 10.179)]。而鸦片组(n=64)和结晶甲基苯丙胺组(n=37)在弓形虫IgG和IgM抗体及血中弓形虫存在方面无显著差异(P>0.05)。结论:血清学和分子检测结果表明,麻醉药品依赖者感染的爆发频率高于对照组。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Central nervous system agents in medicinal chemistry
Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology
CiteScore
2.10
自引率
0.00%
发文量
21
期刊介绍: Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.
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