Prognostic implications of the EGFR polymorphism rs763317 and clinical variables among young Chinese lung cancer population.

IF 2 4区 医学 Q3 ONCOLOGY
Zheng-Xing Li, Fan Wang, Zhen-Yu Sun, Chang Xu, Zi-Xiu Zou, Zong-Xu Zhao, Hai-Jian Wang, Shi-Cheng Guo, Li Jin, Qiang Li, Jiu-Cun Wang, Fan Xia, Xiao-Qiang Yue, Junjie Wu
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引用次数: 0

Abstract

The 5-year survival rate for patients with lung cancer, the world's second most frequent malignant tumor, is less than 20%, and its prognosis cannot be clearly predicted. Our aim was to analyze the epidermal growth factor receptor (EGFR) rs763317 (G>A) single nucleotide polymorphism and its association with prognosis in Chinese Han lung cancer patients. 839 patients with primary lung cancer were recruited, and genomic DNA was extracted and genotyped by SNPscan. Kaplan-Meier technique and multivariate Cox proportional hazards model were used to analyze the association between prognosis and EGFR polymorphism rs763317. A significant association after stratification by age, significantly increased lung cancer risk was associated with the AA homozygous genotype of rs763317 (adjusted hazard ratio = 2.53, 95% CI: 1.31-4.88, p=0.005), and conferred a poor survival for lung cancer patients (MST: median survival time: 13.6 months) compared with GG genotype (MST: 41.5 months), and in the recessive model AA genotype (AA vs. GG + GA; adjusted hazard ratio = 2.57, 95% CI: 1.34-4.93, p=0.004) who were young (<60 years) had a significantly increased risk of death. The EGFR polymorphism rs763617 might serve as a significant genetic marker for predicting the prognosis of lung cancer.

EGFR多态性rs763317和临床变量对中国年轻肺癌人群预后的影响
肺癌是世界上发病率第二高的恶性肿瘤,其患者的5年生存率不到20%,其预后也无法明确预测。目的分析中国汉族肺癌患者表皮生长因子受体(EGFR) rs763317 (G>A)单核苷酸多态性及其与预后的关系。招募839例原发性肺癌患者,提取基因组DNA并通过SNPscan进行基因分型。采用Kaplan-Meier技术和多变量Cox比例风险模型分析预后与EGFR多态性rs763317的相关性。按年龄分层后,显著增加的肺癌风险与rs763317的AA纯合基因型相关(校正风险比= 2.53,95% CI: 1.31-4.88, p=0.005),并且与GG基因型(MST: 41.5个月)相比,肺癌患者的生存期较差(MST:中位生存时间:13.6个月),在隐性模型中,AA基因型(AA vs GG + GA;校正风险比= 2.57,95% CI: 1.34-4.93, p=0.004)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neoplasma
Neoplasma 医学-肿瘤学
CiteScore
5.40
自引率
0.00%
发文量
238
审稿时长
3 months
期刊介绍: The journal Neoplasma publishes articles on experimental and clinical oncology and cancer epidemiology.
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