Spectrum of EEG Findings in Patients with Leptomeningeal Carcinomatosis and Seizures: Correlation with Neurodiagnostic Results and Outcome.

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY
Cansu Ayvacioglu Cagan, Ezgi Demirel Ozbek, Nese Dericioglu
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引用次数: 1

Abstract

Purpose: Leptomeningeal carcinomatosis (LC) is a devastating condition in patients with systemic malignancies or primary brain tumors. Although much is known about neuro-radiologic investigations, there is very little information about EEG findings in these patients. Whether EEG is correlated with cranial magnetic resonance imaging (MRI) results and survival has not been investigated. Methods: Medical records of 2340 adult patients with the diagnosis of brain tumor, either metastatic (Group 1) or primary (Group 2), between 2000-2021 were reviewed for the presence of LC and seizures. Demographic and clinical features, laboratory results and Karnofsky performance scores of included patients were noted. Available routine EEG recordings were re-evaluated. Any possible correlation between EEG findings-MRI and EEG findings-survival were investigated statistically. Results: Sixty-six patients with LC and seizures were identified. The most common malignancies were lung cancer and glioblastoma multiforme. Twenty-six EEG recordings of 17 patients in Group 1, and 13 EEGs of 9 patients in Group 2 were available for final analysis. The most common EEG characteristic was background slowing (73%). The most frequent findings were rhythmic periodic patterns or spike wave activity (27%). Sporadic epileptiform discharges (8%) or ictal recordings (4%) were very rare. None of the EEG features correlated with MRI results or survival. Conclusion: There are various EEG patterns in patients with LC and seizures. The most common findings are related to background activity, with rhythmic periodic patterns or spike wave activity being observed less commonly. EEG characteristics do not predict MRI findings or survival.

脑膜轻脑膜癌和癫痫患者的脑电图频谱:与神经诊断结果和预后的相关性。
目的:脑膜轻脑膜癌(LC)是系统性恶性肿瘤或原发性脑肿瘤患者的一种破坏性疾病。虽然我们对神经影像学检查了解很多,但对这些患者的脑电图检查却知之甚少。脑电图是否与颅磁共振成像(MRI)结果和生存率相关尚未研究。方法:回顾2000-2021年间2340例诊断为脑肿瘤的成人患者的医疗记录,包括转移性(1组)或原发性(2组),以确定LC和癫痫的存在。记录纳入患者的人口学和临床特征、实验室结果和Karnofsky表现评分。重新评估可用的常规脑电图记录。对脑电图结果(mri)与脑电图结果(生存率)之间可能存在的相关性进行统计学调查。结果:66例LC合并癫痫发作。最常见的恶性肿瘤是肺癌和多形性胶质母细胞瘤。组1有17例患者的26条脑电图记录,组2有9例患者的13条脑电图记录可供最终分析。最常见的EEG特征是背景减慢(73%)。最常见的发现是有节奏的周期模式或尖峰波活动(27%)。散发的癫痫样放电(8%)或发作记录(4%)非常罕见。脑电图特征与MRI结果或生存率均无相关性。结论:LC伴癫痫发作患者的脑电图模式多种多样。最常见的发现与背景活动有关,有节奏的周期模式或尖峰波活动不太常见。脑电图特征不能预测MRI结果或生存率。
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来源期刊
Clinical EEG and Neuroscience
Clinical EEG and Neuroscience 医学-临床神经学
CiteScore
5.20
自引率
5.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Clinical EEG and Neuroscience conveys clinically relevant research and development in electroencephalography and neuroscience. Original articles on any aspect of clinical neurophysiology or related work in allied fields are invited for publication.
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