Ana Caroline Melo Dos Santos, Barbara Rayssa Correia Dos Santos, Bruna Brandão Dos Santos, Edilson Leite de Moura, Abel Barbosa Lira Neto, Aline Cristine Pereira E Silva, Karol Fireman de Farias, Verônica de Medeiros Alves, Antônio Egídio Nardi, Elaine Virgínia Martins de Souza Figueiredo
{"title":"<i>IL-10 (-819C/T), TNFA (-30G/A)</i> and <i>ENOS (-786T/C)</i> Polymorphisms Modulating the Outcome Related to Mental Disorders in Crack Addicted Users.","authors":"Ana Caroline Melo Dos Santos, Barbara Rayssa Correia Dos Santos, Bruna Brandão Dos Santos, Edilson Leite de Moura, Abel Barbosa Lira Neto, Aline Cristine Pereira E Silva, Karol Fireman de Farias, Verônica de Medeiros Alves, Antônio Egídio Nardi, Elaine Virgínia Martins de Souza Figueiredo","doi":"10.2174/17450179-v18-e2201140","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cocaine/crack use affects immune system molecules and development of mental disorders has been identified.</p><p><strong>Objective: </strong>To investigate the relationship of polymorphisms in the <i>TNFA</i> (-308G/A), IL-10 (-819C/T) and <i>ENOS</i> (-786T/C) genes with mental disorders in cocaine and crack users.</p><p><strong>Methods: </strong>A case-control study was carried out, which included 107 cocaine and crack users and 115 controls who never used healthy cocaine and crack. The SNPs in the <i>TNFA</i> (-308G/A), <i>IL-10</i> (-819C/T) and <i>ENOS</i> (-786T/C) genes were genotyped by real time PCR.</p><p><strong>Results: </strong>As for the individuals included in this study, the average age of 31.4 years (± 8.59). We identified that the G/A genotype to TNFA (-308) (OR = 0.24; p = 0.03) and the A allele (OR = 0.30; p = 0.03) were associated with reduced risk for dysthymic disorder. The T allele of the IL-10 (-819) polymorphism was associated with decreased risk of developing panic disorder (OR = 0.44; p = 0.01), while the C allele was correlated with an increased risk for alcohol dependence (OR = 1.97; p = 0.04), alcohol abuse (OR = 1.81; p = 0.04) and psychotic syndrome (OR = 2.23; p = 0.01). C/C genotype was correlated with increased chances of developing current psychotic syndrome (OR = 4.23; p = 0.01).</p><p><strong>Conclusion: </strong>Our results suggest that genetic polymorphisms promote susceptibility or promote protection for clinical phenotypes of psychiatric comorbidities in cocaine and crack users and be considered as good prognostic markers.</p>","PeriodicalId":72621,"journal":{"name":"","volume":"18 ","pages":"e174501792201140"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156023/pdf/","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/17450179-v18-e2201140","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Background: Cocaine/crack use affects immune system molecules and development of mental disorders has been identified.
Objective: To investigate the relationship of polymorphisms in the TNFA (-308G/A), IL-10 (-819C/T) and ENOS (-786T/C) genes with mental disorders in cocaine and crack users.
Methods: A case-control study was carried out, which included 107 cocaine and crack users and 115 controls who never used healthy cocaine and crack. The SNPs in the TNFA (-308G/A), IL-10 (-819C/T) and ENOS (-786T/C) genes were genotyped by real time PCR.
Results: As for the individuals included in this study, the average age of 31.4 years (± 8.59). We identified that the G/A genotype to TNFA (-308) (OR = 0.24; p = 0.03) and the A allele (OR = 0.30; p = 0.03) were associated with reduced risk for dysthymic disorder. The T allele of the IL-10 (-819) polymorphism was associated with decreased risk of developing panic disorder (OR = 0.44; p = 0.01), while the C allele was correlated with an increased risk for alcohol dependence (OR = 1.97; p = 0.04), alcohol abuse (OR = 1.81; p = 0.04) and psychotic syndrome (OR = 2.23; p = 0.01). C/C genotype was correlated with increased chances of developing current psychotic syndrome (OR = 4.23; p = 0.01).
Conclusion: Our results suggest that genetic polymorphisms promote susceptibility or promote protection for clinical phenotypes of psychiatric comorbidities in cocaine and crack users and be considered as good prognostic markers.