Detection of dengue virus serotype 4 in Sudan.

IF 1.7 4区医学 Q3 HEALTH CARE SCIENCES & SERVICES

Eastern Mediterranean Health Journal Pub Date : 2023-06-27 DOI:10.26719/emhj.23.041

Mohamed Desogi, Mostafa Ali, Nesrin Gindeel, Fatima Khalid, Muhannad Abdelraheem, Aymen Alnaby, Mariam Saad, Elwaleed Elamin, Musa Kheir, Maowia Mukhtar

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引用次数: 0

Abstract

Background: Dengue virus infection is spreading globally and most parts of Sudan have witnessed repeated dengue outbreaks, with the detection of DENV-1, DENV-2 and DENV-3 serotypes.

Aims: In this report we describe the dengue fever outbreaks that occurred in eastern Sudan (Kassala and Port Sudan cities) from August to November 2019.

Methods: We enrolled 79 (29.8%) suspected cases from Kassala and 186 (70.2%) from Port Sudan who presented with fever. The participants were medically examined and their clinical signs recorded. Blood samples were collected for complete blood count, detection of anti-dengue virus IgM, detection of NS1 dengue antigen and identification of the virus serotype using RT-PCR.

Results: The main clinical presentations were fever, abdominal pain, joint pain and vomiting, and thrombocytopenia was the main laboratory finding. One hundred and twenty-five blood samples tested positive for the anti-dengue IgM antibody, and 145 were positive for the NS1 antigen. Using RT-PCR, we identified 35 (24%) infections with DENV-2, 100 (69%) with DENV-3 and 10 (7%) with DENV-4 serotypes.

Conclusions: We identified multiple serotypes - DENV-2, DENV-3 and DENV-4 - as the causes of the outbreak. The presence of DENV-4 serotype was documented for the first time in Sudan.

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苏丹4型登革热病毒的检测。

背景:登革热病毒感染正在全球蔓延，苏丹大部分地区多次发生登革热疫情，并发现了DENV-1、DENV-2和DENV-3血清型。在本报告中，我们描述了2019年8月至11月在苏丹东部(卡萨拉和苏丹港城市)发生的登革热疫情。方法:我们收集了来自卡萨拉的79例(29.8%)和来自苏丹港的186例(70.2%)发热疑似病例。对参与者进行了医学检查，并记录了他们的临床症状。采集血标本进行全血计数、抗登革病毒IgM检测、登革热NS1抗原检测和病毒血清型RT-PCR鉴定。结果:以发热、腹痛、关节痛、呕吐为主要临床表现，以血小板减少为主要实验室表现。125份血液样本的抗登革热IgM抗体呈阳性，145份血液样本的NS1抗原呈阳性。使用RT-PCR，我们鉴定出35例(24%)DENV-2感染，100例(69%)DENV-3感染，10例(7%)DENV-4感染。结论:我们确定了多种血清型——DENV-2、DENV-3和DENV-4——是此次暴发的原因。在苏丹首次记录了DENV-4血清型的存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eastern Mediterranean Health Journal HEALTH CARE SCIENCES & SERVICESPUBLIC, ENV-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

3.30

自引率

4.80%

发文量

112

期刊介绍： The Eastern Mediterranean Health Journal, established in 1995, is the flagship health periodical of the World Health Organization Regional Office for the Eastern Mediterranean. The mission of the Journal is to contribute to improving health in the Eastern Mediterranean Region by publishing and publicising quality health research and information with emphasis on public health and the strategic health priorities of the Region. It aims to: further public health knowledge, policy, practice and education; support health policy-makers, researchers and practitioners; and enable health professionals to remain informed of developments in public health. The EMHJ: -publishes original peer-reviewed research and reviews in all areas of public health of relevance to the Eastern Mediterranean Region -encourages, in particular, research related to the regional health priorities, namely: health systems strengthening; emergency preparedness and response; communicable diseases; noncommunicable diseases and mental health; reproductive, maternal, child health and nutrition -provides up-to-date information on public health developments with special reference to the Region. The Journal addresses all members of the health profession, health educational institutes, as well as governmental and nongovernmental organizations in the area of public health within and outside the Region.