Food-derived extracellular vesicles: natural nanocarriers for active phytoconstituents in new functional food.

IF 7.3 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Critical reviews in food science and nutrition Pub Date : 2024-11-01 Epub Date: 2023-08-07 DOI:10.1080/10408398.2023.2242947

Qiao Jiang, Li Wang, Jinlong Tian, Weijia Zhang, Huijun Cui, Hailong Gui, Zhihuan Zang, Bin Li, Xu Si

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引用次数: 0

Abstract

Extracellular vesicles (EVs) are naturally occurring non-replicating particles released from cells, known for their health-promoting effects and potential as carriers for drug delivery. Extensive research has been conducted on delivery systems based on culture-cell-derived EVs. Nevertheless, they have several limitations including low production yield, high expenses, unsuitability for oral administration, and safety concerns in applications. Conversely, food-derived EVs (FDEVs) offer unique advantages that cannot be easily substituted. This review provides a comprehensive analysis of the biogenesis pathways, composition, and health benefits of FDEVs, as well as the techniques required for constructing oral delivery systems. Furthermore, it explores the advantages and challenges associated with FDEVs as oral nanocarriers, and discusses the current research advancements in delivering active phytoconstituents. FDEVs, functioning as a nanocarrier platform for the oral delivery of active molecules, present numerous benefits such as convenient administration, high biocompatibility, low toxicity, and inherent targeting. Nevertheless, numerous unresolved issues persist in the isolation, characterization, drug loading, and application of FDEVs. Technical innovation and standardization of quality control are the key points to promote the development of FDEVs. The review aimed to provide frontier ideas and basic quality control guidelines for developing new functional food based on FDEVs oral drug delivery system.

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源自食物的细胞外囊泡：新型功能食品中活性植物成分的天然纳米载体。

细胞外囊泡（EVs）是从细胞中自然释放出来的非复制颗粒，具有促进健康的作用和作为药物输送载体的潜力。目前已对基于培养细胞衍生 EVs 的递送系统进行了广泛研究。然而，它们存在一些局限性，包括产量低、费用高、不适合口服给药以及应用中的安全问题。相反，源自食物的 EVs（FDEVs）具有不易替代的独特优势。本综述全面分析了 FDEVs 的生物生成途径、组成和对健康的益处，以及构建口服给药系统所需的技术。此外，它还探讨了与 FDEVs 作为口服纳米载体相关的优势和挑战，并讨论了当前在递送活性植物成分方面的研究进展。作为口服给药活性分子的纳米载体平台，FDEVs 具有给药方便、生物相容性高、毒性低和固有靶向性等诸多优点。然而，在 FDEV 的分离、表征、药物负载和应用方面仍存在许多尚未解决的问题。技术创新和质量控制标准化是推动无损检测技术发展的关键点。本综述旨在为开发基于FDEVs口服给药系统的新型功能食品提供前沿思路和基本质量控制指南。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical reviews in food science and nutrition 工程技术-食品科技

CiteScore

22.60

自引率

4.90%

发文量

600

审稿时长

7.5 months

期刊介绍： Critical Reviews in Food Science and Nutrition serves as an authoritative outlet for critical perspectives on contemporary technology, food science, and human nutrition. With a specific focus on issues of national significance, particularly for food scientists, nutritionists, and health professionals, the journal delves into nutrition, functional foods, food safety, and food science and technology. Research areas span diverse topics such as diet and disease, antioxidants, allergenicity, microbiological concerns, flavor chemistry, nutrient roles and bioavailability, pesticides, toxic chemicals and regulation, risk assessment, food safety, and emerging food products, ingredients, and technologies.