Multifunctional hydrogels: advanced therapeutic tools for osteochondral regeneration.

IF 11.3 1区 医学 Q1 Medicine
Wenqian Zhang, Kangkang Zha, Weixian Hu, Yuan Xiong, Samuel Knoedler, Doha Obed, Adriana C Panayi, Ze Lin, Faqi Cao, Bobin Mi, Guohui Liu
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引用次数: 0

Abstract

Various joint pathologies such as osteochondritis dissecans, osteonecrosis, rheumatic disease, and trauma, may result in severe damage of articular cartilage and other joint structures, ranging from focal defects to osteoarthritis (OA). The osteochondral unit is one of the critical actors in this pathophysiological process. New approaches and applications in tissue engineering and regenerative medicine continue to drive the development of OA treatment. Hydrogel scaffolds, a component of tissue engineering, play an indispensable role in osteochondral regeneration. In this review, tissue engineering strategies regarding osteochondral regeneration were highlighted and summarized. The application of hydrogels for osteochondral regeneration within the last five years was evaluated with an emphasis on functionalized physical and chemical properties of hydrogel scaffolds, functionalized delivery hydrogel scaffolds as well as functionalized intelligent response hydrogel scaffolds. Lastly, to serve as guidance for future efforts in the creation of bioinspired hydrogel scaffolds, a succinct summary and new views for specific mechanisms, applications, and existing limitations of the newly designed functionalized hydrogel scaffolds were offered.

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多功能水凝胶:骨软骨再生的先进治疗工具。
各种关节病变,如夹层性骨软骨炎、骨坏死、风湿病和创伤,可能导致关节软骨和其他关节结构的严重损伤,从局灶性缺陷到骨关节炎(OA)。骨软骨单位是这一病理生理过程中的关键角色之一。组织工程和再生医学的新方法和应用继续推动OA治疗的发展。水凝胶支架作为组织工程的重要组成部分,在骨软骨再生中发挥着不可替代的作用。本文综述了组织工程技术在骨软骨再生方面的研究进展。综述了近五年来水凝胶在骨软骨再生中的应用,重点从功能化的水凝胶支架、功能化的传递型水凝胶支架以及功能化的智能响应型水凝胶支架等方面进行了综述。最后,对新设计的功能化水凝胶支架的具体机理、应用和存在的局限性进行了简要总结和新的看法,以指导未来生物仿生水凝胶支架的创建。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomaterials Research
Biomaterials Research Medicine-Medicine (miscellaneous)
CiteScore
10.20
自引率
3.50%
发文量
63
审稿时长
30 days
期刊介绍: Biomaterials Research, the official journal of the Korean Society for Biomaterials, is an open-access interdisciplinary publication that focuses on all aspects of biomaterials research. The journal covers a wide range of topics including novel biomaterials, advanced techniques for biomaterial synthesis and fabrication, and their application in biomedical fields. Specific areas of interest include functional biomaterials, drug and gene delivery systems, tissue engineering, nanomedicine, nano/micro-biotechnology, bio-imaging, regenerative medicine, medical devices, 3D printing, and stem cell research. By exploring these research areas, Biomaterials Research aims to provide valuable insights and promote advancements in the biomaterials field.
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