Unusual Manifestation of Extraosseous Ewing Sarcoma: Report of 3 Cases.

IF 0.5 4区医学 Q4 GENETICS & HEREDITY

Balkan Journal of Medical Genetics Pub Date : 2023-05-01 DOI:10.2478/bjmg-2022-0022

M Ioannidou, E Tsotridou, E Samoladas, A Tragiannidis, K Kouskouras, D Sfougaris, I Spyridakis, C Foroulis, A Galli-Tsinopoulou, E Hatzipantelis

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引用次数: 1

Abstract

Ewing sarcoma (ES), described as a diffuse endothelioma of the bone, is divided into two categories: osseous and extraosseous, which mainly affects adolescents. Extraosseous Ewing Sarcomas (EES) are rare tumors originating from soft tissues. Their clinical presentation depends mainly on the primary location of the tumor and are highly chemosensitive and radiosensitive. The purpose of this study was to describe the clinical characteristics and outcomes of 3 children with EES and uncommon presentation treated in our Unit. The diagnosis of EES was confirmed by biopsy and cytogenetic analysis with fluorescence in situ hybridization (FISH). Surgical excision was planned as primary treatment, followed by adjuvant chemotherapy according to EURO-E.W.I.N.G protocol. To date, all patients are alive, 1, 3 and 4 years after completion of treatment, with no signs of recurrence or metastasis.

Abstract Image

查看原文本刊更多论文

骨外尤文氏肉瘤的异常表现:附3例报告。

尤文氏肉瘤(ES)是一种骨的弥漫性内皮瘤，分为骨性和骨外两类，主要影响青少年。骨外尤文氏肉瘤(EES)是一种罕见的起源于软组织的肿瘤。其临床表现主要取决于肿瘤的原发部位，对化学和放射高度敏感。本研究的目的是描述3例在我们病房治疗的EES和罕见症状的儿童的临床特征和结果。活检和荧光原位杂交(FISH)细胞遗传学分析证实了EES的诊断。根据EURO-E.W.I.N，计划手术切除作为主要治疗，然后进行辅助化疗。G协议。迄今为止，所有患者在完成治疗后的1年、3年和4年都存活，没有复发或转移的迹象。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Balkan Journal of Medical Genetics 医学-遗传学

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Balkan Journal of Medical Genetics is a journal in the English language for publication of articles involving all branches of medical genetics: human cytogenetics, molecular genetics, clinical genetics, immunogenetics, oncogenetics, pharmacogenetics, population genetics, genetic screening and diagnosis of monogenic and polygenic diseases, prenatal and preimplantation genetic diagnosis, genetic counselling, advances in treatment and prevention.