Stimulation of spinal cord according to recorded theta hippocampal rhythm during rat move on treadmill.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-08-28 DOI:10.1515/bmt-2022-0420

Shahin Rouhi, Saeid Rahmani, Faezeh Shanesazzadeh, Tala Ahmadvand, Mahrokh Namazi, Mehdi Fardmanesh, Sahar Kiani

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引用次数: 0

Abstract

Objectives: Several studies have revealed that after spinal cord injury (SCI), in acute and sub-acute phase the spinal cord neurons below the injury are alive and could stimulate by use of electrical pulses. Spinal cord electrical stimulation could generate movement for paralyzed limbs and is a rehabilitation strategy for paralyzed patients. An innovative idea for controlling spinal cord electrical stimulation onset time is presented in current study.

Methods: In our method, the time of applying electrical pulse on the spinal cord is according to rat behavioral movement and two movements behaviors are recognized only based on rat EEG theta rhythm on the treadmill line. Briefly, 5 rats were placed on the treadmill and the animals experienced zero or 12 m/min speeds.

Results: These speeds were recognized based on EEG signals and off-line periodogram analysis. Finally, the electrical stimulation pulses had been applied to the spinal cord if the results of the EEG analysis had detected running behavior.

Conclusions: These findings may guide future research in utilizing theta rhythms for the recognition of animal motor behavior and designing electrical stimulation systems based on it.

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根据记录的海马节律对大鼠在跑步机上运动时脊髓的刺激。

目的:多项研究表明，脊髓损伤后，在急性和亚急性期，损伤下方的脊髓神经元是活的，可以用电脉冲刺激。脊髓电刺激可以产生瘫痪肢体的运动，是瘫痪患者的一种康复策略。目前的研究提出了一种控制脊髓电刺激开始时间的创新思路。方法:在本方法中，电脉冲在脊髓上施加的时间是根据大鼠的行为运动，两种运动行为仅根据大鼠在跑步机上的脑电图θ节奏来识别。简单地说，5只大鼠被放在跑步机上，动物经历0或12米/分钟的速度。结果:基于脑电信号和离线周期图分析，识别出这些速度。最后，如果脑电图分析的结果检测到奔跑行为，则将电刺激脉冲应用于脊髓。结论:这些发现可以指导未来利用θ波节律识别动物运动行为和设计基于它的电刺激系统的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.