Comparison of Endoplasmic Reticulum Stress Messenger Ribonucleic Acid Expression Between Chronic Otitis Media With and Without Cholesteatoma.

IF 1 4区医学 Q3 OTORHINOLARYNGOLOGY

Journal of International Advanced Otology Pub Date : 2023-07-01 DOI:10.5152/iao.2023.21182

Dae Woong Kang, Sang Hoon Kim, Sung Soo Kim, Young Il Kim, Yong Jun Kim, Jeon Gang Doo, Seung Geun Yeo

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引用次数: 0

Abstract

Background: We evaluated and compared the role of endoplasmic reticulum stress in chronic otitis media with cholesteatoma and chronic otitis media without cholesteatoma.

Methods: The messenger ribonucleic acid expression of endoplasmic reticulum stress was measured and compared between chronic otitis media with cholesteatoma and chronic otitis media without cholesteatoma according to the presence or absence of bacteria, type of hearing loss, ossicle destruction, and facial canal dehiscence.

Results: The expression of immunoglobulin heavy chain-binding protein messenger ribonucleic acid was higher in the chronic otitis media without cholesteatoma group than in the chronic otitis media with cholesteatoma group, and Protein kinase RNA (PKR)-like endoplasmic reticulum kinase and activating transcription factor 6 messenger ribonucleic acid expression were higher in the chronic otitis media with cholesteatoma group than in the chronic otitis media without cholesteatoma group.

Conclusion: Endoplasmic reticulum stress messenger ribonucleic acids were expressed in both chronic otitis media with cholesteatoma and chronic otitis media without cholesteatoma. The levels of expression of endoplasmic reticulum stress messenger ribonucleic acids differed according to clinical features, suggesting that different endoplasmic reticulum stress pathways are involved in the pathophysiology of different types of chronic otitis media.

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慢性中耳炎合并和不合并胆脂瘤患者内质网应激信使核糖核酸表达的比较。

背景：我们评估并比较了内质网应激在伴有胆脂瘤的慢性中耳炎和无胆脂瘤慢性中耳炎中的作用。方法：根据细菌的存在与否、听力损失类型、听小骨破坏和面管破裂，测量并比较有胆脂瘤的慢性中耳炎和无胆脂瘤慢性中耳炎的内质网应激信使核糖核酸表达。结果：无胆脂瘤的慢性中耳炎组免疫球蛋白重链结合蛋白信使核糖核酸的表达高于有胆脂瘤组，蛋白激酶RNA（PKR）样内质网激酶和激活转录因子6信使核糖核酸在有胆脂瘤的慢性中耳炎组中的表达高于无胆脂瘤组。结论：内质网应激信使核糖核酸在伴有胆脂瘤的慢性中耳炎和无胆脂瘤慢性中耳炎中均有表达。内质网应激信使核糖核酸的表达水平因临床特征而异，这表明不同类型的慢性中耳炎的病理生理学涉及不同的内质网应激途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of International Advanced Otology OTORHINOLARYNGOLOGY-

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of International Advanced Otology (IAO – Citation Abbreviation: J Int Adv Otol) is an open access double-blind peer-reviewed, international publication. The Journal of International Advanced Otology is fully sponsored and owned by the European Academy of Otology and Neurotology and the Politzer Society. The Journal of International Advanced Otology is published 3 times per year on April, August, December and its publication language is English. The scope of the Journal is limited with otology, neurotology, audiology (excluding linguistics) and skull base medicine. The Journal of International Advanced Otology aims to publish manuscripts at the highest clinical and scientific level. IAO publishes original articles in the form of clinical and basic research, review articles, short reports and a limited number of case reports. Controversial patient discussions, communications on emerging technology, and historical issues will also be considered for publication.