Yield of family screening in dilated cardiomyopathy within low-income setting: Tanzanian experience.

IF 0.7 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Journal of Africa Pub Date : 2023-07-25 DOI:10.5830/CVJA-2023-037

L S Fundikira, J Julius, P Chillo, H Mayala, E Kifai, L W van Laake, A Kamuhabwa, G Kwesigabo, F W Asselbergs

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引用次数: 0

Abstract

Background: Dilated cardiomyopathy (DCM) is often familial and screening of relatives is recommended. However, studies on the yield of screening are scarce in developing countries.

Aim: The aim of the study was to identify and characterise First-degree relatives of patients with DCM in Tanzania.

Methods: We recruited first-degree relatives of 57 DCM patients. DCM in the relatives was diagnosed using the 2016 revised definition by the European Society of Cardiology working group on myocardial and pericardial diseases.

Results: We screened 120 first-degree relatives. All were asymptomatic (100%) with a median age of 39.0 years (29.5-49.0), slightly over a half (53.3%) were females and 17 (14.1%) were found to have previously unknown DCM. The mean (± SD) indexed left ventricular end-diastolic volume was significantly higher in relatives with DCM (71 ± 11.5 ml) compared to relatives without DCM (50 ± 11.5) (p = 0.001).

Conclusion: First-degree relatives of patients with DCM are at risk of developing asymptomatic DCM at a young age.

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扩张型心肌病的家庭筛查在低收入环境的产量:坦桑尼亚的经验。

背景:扩张型心肌病(DCM)通常是家族性的，建议进行亲属筛查。然而，在发展中国家，关于筛查产量的研究很少。目的:该研究的目的是识别和表征坦桑尼亚DCM患者的一级亲属。方法:我们招募了57例DCM患者的一级亲属。根据欧洲心脏病学会心肌和心包疾病工作组2016年修订的定义，诊断亲属的DCM。结果:筛选一级直系亲属120例。所有患者均无症状(100%)，中位年龄为39.0岁(29.5-49.0岁)，略超过一半(53.3%)为女性，17例(14.1%)发现以前未知的DCM。DCM亲属左室舒张末期容积(71±11.5 ml)的平均值(±SD)高于无DCM亲属(50±11.5 ml) (p = 0.001)。结论:DCM患者的一级亲属在年轻时有发生无症状DCM的危险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Journal of Africa CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Cardiovascular Journal of Africa (CVJA) is an international peer-reviewed journal that keeps cardiologists up to date with advances in the diagnosis and treatment of cardiovascular disease. Topics covered include coronary disease, electrophysiology, valve disease, imaging techniques, congenital heart disease (fetal, paediatric and adult), heart failure, surgery, and basic science.