An autopsy case of progressive supranuclear palsy treated with monoclonal antibody against tau.

IF 1.3 4区 医学 Q4 CLINICAL NEUROLOGY
Neuropathology Pub Date : 2023-08-01 Epub Date: 2023-01-02 DOI:10.1111/neup.12890
Goichi Beck, Rika Yamashita, Kansuke Kido, Kensuke Ikenaka, Tomoya Chiba, Yuki Yonenobu, Yuko Saito, Eiichi Morii, Masato Hasegawa, Shigeo Murayama, Hideki Mochizuki
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引用次数: 0

Abstract

We report an autopsy case of progressive supranuclear palsy (PSP-Richardson syndrome). The individual had been enrolled in a phase 2 trial and received a monoclonal tau antibody (tilavonemab, ABBV-8E12); he died of intrahepatic cholangiocarcinoma and gastrointestinal bleeding during the clinical trial. Neuropathological examination demonstrated neuronal loss, gliosis, and widespread deposits of phosphorylated tau in the neurofibrillary tangles, tufted astrocytes, coiled bodies, and threads, which mainly occurred in the inferior olive nucleus, dentate nucleus of the cerebellum, substantia nigra, midbrain tegmentum, subthalamic nuclei, globus pallidus, putamen, and precentral gyrus, confirming typical PSP pathology. Phosphorylated tau was also found to accumulate in Betz cells, Purkinje cells, and pencil fibers in the basal ganglia. In conclusion, no additional changes or pathological modifications, which were expected from immunotherapy targeting tau, were visible in the present case.

用抗 tau 的单克隆抗体治疗进行性核上性麻痹的尸检病例。
我们报告了一例进行性核上性麻痹(PSP-理查森综合征)尸检病例。该患者参加了一项二期临床试验,并接受了一种单克隆tau抗体(tilavonemab,ABBV-8E12)治疗;在临床试验期间,他死于肝内胆管癌和消化道出血。神经病理学检查显示神经元缺失、胶质增生,磷酸化tau广泛沉积在神经纤维缠结、丛星形胶质细胞、盘状体和线状体中,主要发生在下橄榄核、小脑齿状核、黑质、中脑被盖体、丘脑下核、苍白球、普门和前中央回,证实了典型的PSP病理。在基底节的 Betz 细胞、Purkinje 细胞和铅笔纤维中也发现了磷酸化 tau 的聚集。总之,在本病例中未发现针对tau的免疫疗法所预期的其他变化或病理改变。
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来源期刊
Neuropathology
Neuropathology 医学-病理学
CiteScore
4.10
自引率
4.30%
发文量
105
审稿时长
6-12 weeks
期刊介绍: Neuropathology is an international journal sponsored by the Japanese Society of Neuropathology and publishes peer-reviewed original papers dealing with all aspects of human and experimental neuropathology and related fields of research. The Journal aims to promote the international exchange of results and encourages authors from all countries to submit papers in the following categories: Original Articles, Case Reports, Short Communications, Occasional Reviews, Editorials and Letters to the Editor. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.
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