Oxidative metabolism of neutrophils in acute coronary syndrome.

IF 0.7 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Journal of Africa Pub Date : 2023-07-25 DOI:10.5830/CVJA-2023-032

Elena Proskurnina, Tatiana Danilova, Madina Sozarukova, Artem Snitsar, Anatoly Baranov

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引用次数: 0

Abstract

Background: Inflammation in acute coronary syndrome (ACS) involves neutrophil activation and oxidative stress. Here, we studied the production of reactive oxygen species (ROS) by neutrophils in ACS.

Methods: The study included 42 patients, men and women aged 46-91 years with ischaemic heart disease (IHD), non-ST-segment elevation ACS and ST-segment elevation ACS. Neutrophil-derived ROS were quantified with double-step stimulated luminol-enhanced chemiluminometry.

Results: The specific indices of spontaneous and double-step stimulated chemiluminescence did not differ in the subgroups of IHD, non-ST-segment elevation ACS and ST-segment elevation ACS. The total double-step stimulated ROS production by neutrophils was significantly higher in ST-segment elevation ACS than in non-ST-segment elevation ACS and IHD.

Conclusions: In ACS, special activation mechanisms of peripherical neutrophils were not triggered in our study. The significant increase in free radical production by neutrophils in acute myocardial infarction was presumably a consequence of an increase in their number.

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急性冠脉综合征中性粒细胞的氧化代谢。

背景:急性冠脉综合征(ACS)的炎症涉及中性粒细胞活化和氧化应激。在这里，我们研究了ACS中中性粒细胞产生活性氧(ROS)。方法:纳入42例缺血性心脏病(IHD)、非st段抬高型ACS和st段抬高型ACS患者，年龄46 ~ 91岁。中性粒细胞来源的ROS采用双步刺激发光醇增强化学光度法定量。结果:IHD亚组、非st段抬高ACS亚组和st段抬高ACS亚组的自发和双步刺激化学发光特异性指标无差异。在st段抬高ACS中，中性粒细胞产生的双步刺激ROS总量明显高于非st段抬高ACS和IHD。结论:在我们的研究中，ACS未触发外周中性粒细胞的特殊激活机制。急性心肌梗死中中性粒细胞自由基产生的显著增加可能是其数量增加的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Journal of Africa CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Cardiovascular Journal of Africa (CVJA) is an international peer-reviewed journal that keeps cardiologists up to date with advances in the diagnosis and treatment of cardiovascular disease. Topics covered include coronary disease, electrophysiology, valve disease, imaging techniques, congenital heart disease (fetal, paediatric and adult), heart failure, surgery, and basic science.