Frailty Resilience Score: A Novel Measure of Frailty Resilience Associated With Protection From Frailty and Survival.

IF 4.3 2区医学 Q1 GERIATRICS & GERONTOLOGY

Journals of Gerontology Series A-Biological Sciences and Medical Sciences Pub Date : 2023-10-09 DOI:10.1093/gerona/glad138

Sofiya Milman, Ben Lerman, Emmeline Ayers, Zhengdong Zhang, Sanish Sathyan, Morgan Levine, Kenny Ye, Tina Gao, Albert Higgins-Chen, Nir Barzilai, Joe Verghese

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引用次数: 0

Abstract

Frailty is characterized by increased vulnerability to disability and high risk for mortality in older adults. Identification of factors that contribute to frailty resilience is an important step in the development of effective therapies that protect against frailty. First, a reliable quantification of frailty resilience is needed. We developed a novel measure of frailty resilience, the Frailty Resilience Score (FRS), that integrates frailty genetic risk, age, and sex. Application of FRS to the LonGenity cohort (n = 467, mean age 74.4) demonstrated its validity compared to phenotypic frailty and its utility as a reliable predictor of overall survival. In a multivariable-adjusted analysis, 1-standard deviation increase in FRS predicted a 38% reduction in the hazard of mortality, independent of baseline frailty (p < .001). Additionally, FRS was used to identify a proteomic profile of frailty resilience. FRS was shown to be a reliable measure of frailty resilience that can be applied to biological studies of resilience.

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脆弱复原力得分：一种新的脆弱复原力测量方法，与抵御脆弱和生存相关。

虚弱的特点是老年人更容易残疾，死亡率高。识别有助于抵御虚弱的因素是开发有效治疗虚弱的重要一步。首先，需要对脆弱性和复原力进行可靠的量化。我们开发了一种新的虚弱恢复力测量方法，即虚弱恢复力评分（FRS），该评分综合了虚弱遗传风险、年龄和性别。FRS在LonGenity队列（n=467，平均年龄74.4）中的应用证明了其与表型虚弱相比的有效性，以及其作为总生存率可靠预测指标的实用性。在一项多变量调整分析中，FRS的1标准差增加预测死亡率降低38%，与基线虚弱无关（p<.001）。此外，FRS还用于确定虚弱恢复力的蛋白质组学特征。FRS被证明是一种可靠的脆弱性恢复力测量方法，可应用于恢复力的生物学研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journals of Gerontology Series A-Biological Sciences and Medical Sciences 医学-老年医学

CiteScore

10.00

自引率

5.90%

发文量

233

审稿时长

3-8 weeks

期刊介绍： Publishes articles representing the full range of medical sciences pertaining to aging. Appropriate areas include, but are not limited to, basic medical science, clinical epidemiology, clinical research, and health services research for professions such as medicine, dentistry, allied health sciences, and nursing. It publishes articles on research pertinent to human biology and disease.