Androgen-based therapies in women

IF 6.1 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Kath Whitton (Obstetrician, Gynaecologist, Fertility Specialist) , Rodney Baber (Clinical Professor of Obstetrics and Gynaecology)
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引用次数: 0

Abstract

Androgens play a key biological role in libido and sexual arousal in women, and knowledge about their complex role in other systems remains ambiguous and incomplete. This narrative review examines the role of endogenous androgens in women’s health throughout the life span before focusing on evidence surrounding the use of androgen-based therapies to treat postmenopausal women. The role of testosterone as a therapeutic agent in women continues to attract controversy as approved preparations are rare, and use of off-label and compounded formulations is widespread. Despite this androgen therapy has been used for decades in oral, injectable, and transdermal formulations. Responses to androgen therapy have been demonstrated to improve aspects of female sexual dysfunction, notably hypoactive sexual desire disorder, in a dose related manner. Substantial research has also been conducted into the role of androgens in treating aspects of the genitourinary syndrome of menopause (GSM). Evidence for benefits beyond these is mixed and more research is required regarding long-term safety. However, It remains biologically plausible that androgens will be effective in treating hypoestrogenic symptoms related to menopause, either through direct physiological effects or following aromatization to estradiol throughout the body.

妇女的雄激素疗法
雄激素在女性的性欲和性唤起中发挥着关键的生物学作用,而关于雄激素在其他系统中的复杂作用的知识仍然模糊不清、不完整。这篇叙述性综述探讨了内源性雄激素在女性一生中的健康中所起的作用,然后重点介绍了使用雄激素疗法治疗绝经后妇女的相关证据。睾酮作为一种治疗药物在女性中的作用一直备受争议,因为获得批准的制剂很少,而标签外制剂和复方制剂的使用非常普遍。尽管如此,口服、注射和透皮制剂的雄激素疗法已使用了几十年。事实证明,雄激素疗法可以改善女性性功能障碍,尤其是性欲减退,而且与剂量有关。此外,还对雄激素在治疗更年期泌尿生殖系统综合征(GSM)方面的作用进行了大量研究。除此以外,其他益处的证据不一,还需要对长期安全性进行更多研究。不过,从生物学角度看,雄激素通过直接的生理作用或在体内芳香化为雌二醇后,仍可有效治疗与更年期有关的雌激素过低症状。
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来源期刊
CiteScore
11.90
自引率
0.00%
发文量
77
审稿时长
6-12 weeks
期刊介绍: Best Practice & Research Clinical Endocrinology & Metabolism is a serial publication that integrates the latest original research findings into evidence-based review articles. These articles aim to address key clinical issues related to diagnosis, treatment, and patient management. Each issue adopts a problem-oriented approach, focusing on key questions and clearly outlining what is known while identifying areas for future research. Practical management strategies are described to facilitate application to individual patients. The series targets physicians in practice or training.
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