Type 1 Diabetes Genetic Risk Score Differentiates Subgroups of Ketosis-Prone Diabetes.

IF 14.8 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes Care Pub Date : 2023-10-01 DOI:10.2337/dc23-0622

Deborah Osafehinti, Surya N Mulukutla, Christiane S Hampe, Ruchi Gaba, Nalini Ram, Michael N Weedon, Richard A Oram, Ashok Balasubramanyam

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引用次数: 0

Abstract

Objective: To determine whether genetic risk for type 1 diabetes (T1D) differentiates the four Aβ subgroups of ketosis-prone diabetes (KPD), where A+ and A- define the presence or absence of islet autoantibodies and β+ and β- define the presence or absence of β-cell function.

Research design and methods: We compared T1D genetic risk scores (GRS) of patients with KPD across subgroups, race/ethnicity, β-cell function, and glycemia.

Results: Among 426 patients with KPD (54% Hispanic, 31% African American, 11% White), rank order of GRS was A+β- > A+β+ = A-β- > A-β+. GRS of A+β- KPD was lower than that of a T1D cohort, and GRS of A-β+ KPD was higher than that of a type 2 diabetes cohort. GRS was lowest among African American patients, with a similar distribution across KPD subgroups.

Conclusions: T1D genetic risk delineates etiologic differences among KPD subgroups. Patients with A+β- KPD have the highest and those with A-β+ KPD the lowest GRS.

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1型糖尿病遗传风险评分区分酮症酸中毒易患糖尿病的亚组。

目的：确定1型糖尿病（T1D）的遗传风险是否区分酮症易发性糖尿病（KPD）的四个Aβ亚组，其中A+和A-定义胰岛自身抗体的存在与否，β+和β-定义β细胞功能的存在与不存在。研究设计和方法：我们比较了不同亚组、种族/民族、β细胞功能和血糖的KPD患者的T1D遗传风险评分（GRS）。结果：426例KPD患者（54%为西班牙裔，31%为非裔美国人，11%为白人）中，GRS的等级顺序为A+β->A+β+=A-β->A-β+。A+β-KPD的GRS低于T1D队列，A-β+KPD的GRS高于2型糖尿病队列。GRS在非裔美国人中最低，在KPD亚组中的分布相似。结论：T1D遗传风险反映了KPD亚组之间的病因差异。A+β-KPD患者GRS最高，A-β+KPD患者GRS最低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes Care 医学-内分泌学与代谢

CiteScore

27.80

自引率

4.90%

发文量

449

审稿时长

1 months

期刊介绍： The journal's overarching mission can be captured by the simple word "Care," reflecting its commitment to enhancing patient well-being. Diabetes Care aims to support better patient care by addressing the comprehensive needs of healthcare professionals dedicated to managing diabetes. Diabetes Care serves as a valuable resource for healthcare practitioners, aiming to advance knowledge, foster research, and improve diabetes management. The journal publishes original research across various categories, including Clinical Care, Education, Nutrition, Psychosocial Research, Epidemiology, Health Services Research, Emerging Treatments and Technologies, Pathophysiology, Complications, and Cardiovascular and Metabolic Risk. Additionally, Diabetes Care features ADA statements, consensus reports, review articles, letters to the editor, and health/medical news, appealing to a diverse audience of physicians, researchers, psychologists, educators, and other healthcare professionals.