MYCN amplification in spinal ependymoma: A five-year retrospective study.

IF 1.3 4区医学 Q4 CLINICAL NEUROLOGY

Neuropathology Pub Date : 2023-12-01 Epub Date: 2023-05-23 DOI:10.1111/neup.12912

Shilpa Rao, Harsha Sugur, Subhas Konar, Arimappamagan Arivazhagan, Vani Santosh

引用次数: 1

Abstract

Spinal ependymoma with MYCN amplification is a newly recognized type of spinal ependymoma that is known to be associated with poor prognosis. Available studies on this relatively rare tumor type have observed that these tumors tend to disseminate along the spinal cord and behave aggressively with worse overall and progression-free survival compared to the other types of ependymoma. In this study, we describe the clinical and histopathological features of spinal ependymomas in a single institution cohort with emphasis on those with MYCN amplification.

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脊髓室管膜瘤中MYCN扩增:一项五年回顾性研究。

伴MYCN扩增的脊髓室管膜瘤是一种新发现的与预后不良相关的脊髓室管膜瘤。对这种相对罕见的肿瘤类型的现有研究已经观察到，与其他类型的室管膜瘤相比，这些肿瘤倾向于沿脊髓扩散，具有侵袭性，总体生存率和无进展生存率较差。在这项研究中，我们在单一机构队列中描述了脊髓室管膜瘤的临床和组织病理学特征，重点是MYCN扩增的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropathology 医学-病理学

CiteScore

4.10

自引率

4.30%

发文量

105

审稿时长

6-12 weeks

期刊介绍： Neuropathology is an international journal sponsored by the Japanese Society of Neuropathology and publishes peer-reviewed original papers dealing with all aspects of human and experimental neuropathology and related fields of research. The Journal aims to promote the international exchange of results and encourages authors from all countries to submit papers in the following categories: Original Articles, Case Reports, Short Communications, Occasional Reviews, Editorials and Letters to the Editor. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.