{"title":"Possible association between Toxoplasma gondii infection and sleep disorders: A systematic review.","authors":"Tooran Nayeri, Shahabeddin Sarvi, Ahmad Daryani","doi":"10.2174/1871526523666230727093926","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Few studies investigated the relationship between toxoplasmosis and sleep disorders. Sleep disorders can lead to suicidal behavior and traffic accidents. Therefore, the purpose of this study is to collect information and investigate the possible relationship between Toxoplasma gondii (T. gondii) and sleep disorders.</p><p><strong>Methods: </strong>To achieve the goal of the present study, five English databases (PubMed, ScienceDirect, Web of Science, Scopus, and ProQuest) were systematically searched for related studies from their inception until October 18, 2022. The obtained articles were screened based on the title, abstract and full text. Then, the quality of the papers investigating the relationship between toxoplasmosis and sleep disorders was evaluated, and finally, the data from the relevant studies were extracted in a Microsoft Excel data sheet.</p><p><strong>Results: </strong>Eight articles (4 case-control and 4 cross-sectional studies) were entered in this systematic review containing 926 patients with sleep disorders and 1877 people without sleep disorders in casecontrol studies, out of which 212 (22.89%) and 392 (20.88%) individuals were positive for anti-T. gondii IgG antibody using different serological methods. Also, 2885 people with sleep disorders were investigated for anti-T. gondii IgG antibody in cross-sectional studies, out of which 1559 (54.03%) cases were positive.</p><p><strong>Conclusion: </strong>The results of this study suggest that T. gondii infection may be a risk factor for sleep disorders. However, the number of related studies is small, and there are contradictions in the findings of these articles. Therefore, further studies are necessary to clarify the possible association between T. gondii infections and sleep disorders.</p>","PeriodicalId":13678,"journal":{"name":"Infectious disorders drug targets","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious disorders drug targets","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1871526523666230727093926","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
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Abstract
Background: Few studies investigated the relationship between toxoplasmosis and sleep disorders. Sleep disorders can lead to suicidal behavior and traffic accidents. Therefore, the purpose of this study is to collect information and investigate the possible relationship between Toxoplasma gondii (T. gondii) and sleep disorders.
Methods: To achieve the goal of the present study, five English databases (PubMed, ScienceDirect, Web of Science, Scopus, and ProQuest) were systematically searched for related studies from their inception until October 18, 2022. The obtained articles were screened based on the title, abstract and full text. Then, the quality of the papers investigating the relationship between toxoplasmosis and sleep disorders was evaluated, and finally, the data from the relevant studies were extracted in a Microsoft Excel data sheet.
Results: Eight articles (4 case-control and 4 cross-sectional studies) were entered in this systematic review containing 926 patients with sleep disorders and 1877 people without sleep disorders in casecontrol studies, out of which 212 (22.89%) and 392 (20.88%) individuals were positive for anti-T. gondii IgG antibody using different serological methods. Also, 2885 people with sleep disorders were investigated for anti-T. gondii IgG antibody in cross-sectional studies, out of which 1559 (54.03%) cases were positive.
Conclusion: The results of this study suggest that T. gondii infection may be a risk factor for sleep disorders. However, the number of related studies is small, and there are contradictions in the findings of these articles. Therefore, further studies are necessary to clarify the possible association between T. gondii infections and sleep disorders.
背景:很少有研究调查弓形虫病与睡眠障碍的关系。睡眠障碍会导致自杀行为和交通事故。因此，本研究的目的是收集资料，探讨弓形虫(弓形虫)与睡眠障碍的可能关系。方法:为了实现本研究的目标，系统地检索了5个英文数据库(PubMed、ScienceDirect、Web of Science、Scopus和ProQuest)从建立到2022年10月18日的相关研究。根据标题、摘要和全文对获得的文章进行筛选。然后对研究弓形虫病与睡眠障碍关系的论文质量进行评价，最后将相关研究的数据提取到Microsoft Excel数据表中。结果:本系统综述纳入8篇文献(4篇病例对照研究和4篇横断面研究)，共纳入926例睡眠障碍患者和1877例非睡眠障碍病例对照研究，其中抗t抗体阳性212例(22.89%)和392例(20.88%)。不同血清学方法检测弓形虫IgG抗体。此外，对2885名睡眠障碍患者的抗t抗体进行了调查。横断面研究中弓形虫IgG抗体阳性1559例(54.03%)。结论:本研究提示弓形虫感染可能是睡眠障碍的危险因素。然而，相关研究的数量较少，并且这些文章的研究结果存在矛盾。因此，有必要进一步研究弓形虫感染与睡眠障碍之间的可能联系。
期刊介绍：
Infectious Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in infectious disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in infectious disorders. As the discovery, identification, characterization and validation of novel human drug targets for anti-infective drug discovery continues to grow, this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.
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