The Nanotech Potential of Curcumin in Pharmaceuticals: An Overview.

Q3 Pharmacology, Toxicology and Pharmaceutics

Current drug discovery technologies Pub Date : 2024-01-01 DOI:10.2174/1570163820666230726125809

Sagar Pardeshi, Popat Mohite, Tanavirsing Rajput, Abhijeet Puri

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Abstract

It is safe to use Curcumin as a cosmetic and therapeutic ingredient in pharmaceutical products. For the uses mentioned above and for fundamental research, it is essential to obtain pure Curcumin from plant sources. There is a requirement for effective extraction and purification techniques that adhere to green chemistry standards for efficiency improvement, process safety, and environmental friendliness. Several outstanding studies have looked into the extraction and purification of Curcumin. This review thoroughly covers the currently available curcumin extraction, synthesis, and transformation techniques. Additionally, Curcumin's poor solubility and low absorption in the human body have limited its potential for pharmaceutical use. However, recent developments in novel curcumin formulations utilizing nanotechnology delivery methods have provided new approaches to transport and maximize the human body's curcumin absorption efficiency. In this review, we explore the various curcumin nanoformulations and the potential medicinal uses of nano curcumin. Additionally, we review the necessary future research directions to recommend Curcumin as an excellent therapeutic candidate.

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姜黄素在制药中的纳米技术潜力：概述。

将姜黄素用作化妆品和医药产品中的治疗成分是安全的。为了满足上述用途和基础研究的需要，必须从植物中提取纯姜黄素。这就要求有效的提取和纯化技术必须符合绿色化学标准，以提高效率、确保工艺安全和环境友好。有几项杰出的研究对姜黄素的提取和纯化进行了探讨。本综述全面介绍了目前可用的姜黄素提取、合成和转化技术。此外，姜黄素在人体内的溶解性差、吸收率低，这也限制了其制药用途的潜力。然而，利用纳米技术给药方法的新型姜黄素制剂的最新发展为运输姜黄素和最大限度地提高人体吸收效率提供了新方法。在这篇综述中，我们探讨了各种姜黄素纳米制剂以及纳米姜黄素的潜在药用价值。此外，我们还回顾了未来必要的研究方向，以推荐姜黄素作为一种优秀的候选疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug discovery technologies Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

3.70

自引率

0.00%

发文量

期刊介绍： Due to the plethora of new approaches being used in modern drug discovery by the pharmaceutical industry, Current Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques and technologies used in drug design and discovery. The journal is the forum for publishing both original research papers and reviews describing novel approaches and cutting edge technologies used in all stages of drug discovery. The journal addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process.