[Dihydroquercetin as a systemic neuroprotector for the prevention and treatment of β-amyloid-associated brain diseases].

Q3 Medicine
A B Katasonov
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引用次数: 0

Abstract

Dihydroquercetin (DHQ) is a plant-derived polyphenol belonging to the group of flavonoids. In models associated with abnormal accumulation of β-amyloid in the brain (Alzheimer's disease and cerebral amyloid angiopathy), DHQ demonstrates the ability to disaggregate toxic forms of β-amyloid and prevent their formation. It is believed that this phenomenon underlies the protective effect of DHQ on brain neurons. However, pharmacokinetic data doubt the central mechanism of action of DHQ because this compound does not penetrate well into the brain. A hypothesis is put forward about the systemic nature of the neuroprotective action of DHQ, since this compound has multiple biological activities at the level of the whole organism. To characterize DHQ (and similar compounds), it is proposed to introduce the term «systemic neuroprotector».

[二氢槲皮素作为系统性神经保护剂预防和治疗β-淀粉样蛋白相关的脑部疾病]。
双氢槲皮素(DHQ)是一种植物源性多酚,属于类黄酮。在与大脑中β-淀粉样蛋白异常积聚(阿尔茨海默病和脑淀粉样蛋白血管病)相关的模型中,DHQ显示出分解有毒形式的β-淀粉样蛋白并阻止其形成的能力。这一现象被认为是DHQ对大脑神经元保护作用的基础。然而,药代动力学数据怀疑DHQ的主要作用机制,因为这种化合物不能很好地渗透到大脑中。由于该化合物在整个生物体水平上具有多种生物活性,因此提出了DHQ神经保护作用的全身性假设。为了描述DHQ(和类似的化合物),建议引入术语“系统性神经保护剂”。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Medicine-Psychiatry and Mental Health
CiteScore
0.80
自引率
0.00%
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0
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