Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis

IF 1.3 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Mohamed Yafout, Rachid Aït Mouss, Houda Bouchafra, Lhoussaine Zarayby, Ibrahim Sbai El-Otmani
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引用次数: 0

Abstract

Benzodiazepines are one of the most widely used classes of drugs around the world. They are medically used in different therapeutic areas including insomnia, anxiety, epilepsy, and anesthesia. Unfortunately, these drugs are very widespread in the illicit market for recreational purposes and cause drug dependence, traffic accidents, and criminality. Furthermore, benzodiazepine misuse leads to acute poisoning cases that often end up in hospital emergency rooms. Therefore, it is crucial for hospitals to possess straightforward and efficient bioanalytical techniques that enable the swift detection of benzodiazepines in biological samples. This review provides a general overview of the different bioanalytical techniques used for the detection and quantification of benzodiazepines in biological samples and emphasizes their suitability for emergency toxicological analyzes.

用于测定生物样品中苯二氮卓类药物的生物分析方法综述及其在紧急毒理学分析中的适用性
苯二氮卓类药物是世界上使用最广泛的药物之一。它们在医学上用于不同的治疗领域,包括失眠、焦虑、癫痫和麻醉。不幸的是,这些药物在非法市场上非常普遍,用于娱乐目的,并导致药物依赖、交通事故和犯罪。此外,苯二氮卓类药物滥用会导致急性中毒病例,这些病例最终往往会出现在医院急诊室。因此,医院拥有直接有效的生物分析技术,能够快速检测生物样本中的苯二氮卓类药物,这一点至关重要。本综述概述了用于检测和定量生物样品中苯二氮卓类药物的不同生物分析技术,并强调了它们适用于紧急毒理学分析。
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来源期刊
Journal of pharmacological and toxicological methods
Journal of pharmacological and toxicological methods PHARMACOLOGY & PHARMACY-TOXICOLOGY
CiteScore
3.60
自引率
10.50%
发文量
56
审稿时长
26 days
期刊介绍: Journal of Pharmacological and Toxicological Methods publishes original articles on current methods of investigation used in pharmacology and toxicology. Pharmacology and toxicology are defined in the broadest sense, referring to actions of drugs and chemicals on all living systems. With its international editorial board and noted contributors, Journal of Pharmacological and Toxicological Methods is the leading journal devoted exclusively to experimental procedures used by pharmacologists and toxicologists.
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