Expulsion and continuation rates of the 52 mg levonorgestrel intrauterine system in adolescents and adult women.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-08-01 DOI:10.1080/13625187.2023.2215366

Eliza Brull, Helymar C Machado, Luis Bahamondes, Cássia R T Juliato

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引用次数: 0

Abstract

Objective: To compare the continuation rates, expulsion, and other reasons for discontinuation of the hormonal intrauterine device with 52 mg of levonorgestrel (52 mg LNG-IUD) in adolescents and adult women.

Methods: We conducted a retrospective cohort study that included 393 women in whom we placed a 52 mg LNG-IUD and followed up to 5 years. We created two retrospective cohorts, one with 131 adolescents (aged between 12 and 19 years) and the other with 262 women aged ≥20 years. Each adolescent was paired with two adult women who had the same parity and who had a 52 mg LNG-IUD inserted on the same day. We used the Mann-Whitney test to compare numerical variables in both groups, the Kaplan-Meier method, and the log-rank test to compare the continuation, expulsion and other reasons for IUD discontinuation of the two groups.

Results: Age of the adolescents and adult women were mean ± SD 18.1 (±1.1) and 31 (±6.8) years, respectively (p = 0.015). Continuation rates by the fifth year of use were 55.6/100 women-years (W-Y) and 70.3/100 W-Y among adolescents and adult women (p = 0.106); and expulsion rates were 8.4/100 and 6.0/100 W-Y, respectively (p = 0.463). Adolescents had a lower continuation rate during 3 to 5 years of follow-up (p = 0.011) and a high rate of removals due to bleeding/pain (18.5 ± 5.7/100 W-Y vs 6.4/100 ± 2.1 W-Y, p = 0.039).

Conclusion: Adolescents who used the 52 mg LNG-IUD showed a lower continuation rate 3-5 years after device placement than adult women. The expulsion rates were similar in both groups.

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52 mg左炔诺孕酮在青少年和成年妇女宫内系统中的排出率和继续率。

目的:比较52 mg左炔诺孕酮(52 mg LNG-IUD)在青少年和成年女性中激素宫内节育器的继续率、排出和其他原因。方法:我们进行了一项回顾性队列研究，包括393名妇女，我们放置了52毫克LNG-IUD，随访5年。我们创建了两个回顾性队列，一个是131名青少年(年龄在12 - 19岁之间)，另一个是262名年龄≥20岁的女性。每个青少年与两名相同胎次的成年女性配对，并在同一天植入了52毫克的LNG-IUD。我们采用Mann-Whitney检验比较两组数值变量，Kaplan-Meier法比较两组宫内节育器继续、排出等原因。结果:青少年和成年女性的年龄分别为18.1(±1.1)岁和31(±6.8)岁(p = 0.015)。在青少年和成年女性中，第5年的延续率分别为55.6/100 W-Y和70.3/100 W-Y (p = 0.106);驱逐率分别为8.4/100和6.0/100 W-Y (p = 0.463)。青少年在3 ~ 5年随访期间的延续率较低(p = 0.011)，但因出血/疼痛而切除的比率较高(18.5±5.7/100 W-Y vs 6.4/100±2.1 W-Y, p = 0.039)。结论:使用52 mg LNG-IUD的青少年在放置后3-5年的延续率低于成年女性。两组的驱逐率相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.