Chrysin Effect Against Gastric Cancer: Focus on its Molecular Mechanisms.

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current molecular pharmacology Pub Date : 2023-01-01 DOI:10.2174/1874467216666230103105725

Seyyed Mohammad Matin Alavi Dana, Tahereh Farkhondeh, Michael Aschner, Majid Darroudi, Helia Samini, Saeed Samarghandian

引用次数: 0

Abstract

Gastric cancer is one of the most prevalent cancers in the world. Various therapeutic modalities have been used for its treatment, but all exhibit severe side effects, establishing the need for novel approaches. Chrysin is a phytomedicine compound belonging to the flavonoid group. It is found in honey and many plants. Its antitumor effects have been documented against gastric cancer cell lines in vitro, establishing its effects are mediated via different pathways and the expression of miRNA. In this review, we summarize the available literature on chrysin and its effects on gastric cancer, focusing on the cellular mechanisms it targets.

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菊花素抗胃癌的分子机制研究

胃癌是世界上最常见的癌症之一。各种治疗方式已被用于治疗，但都表现出严重的副作用，需要新的方法。黄菊花素是一种植物药化合物，属于类黄酮类。它存在于蜂蜜和许多植物中。体外研究证实其对胃癌细胞系的抗肿瘤作用是通过不同途径和miRNA的表达介导的。本文综述了国内外有关菊花素及其对胃癌的作用的文献，重点介绍了其作用的细胞机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current molecular pharmacology Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

4.90

自引率

3.70%

发文量

112

期刊介绍： Current Molecular Pharmacology aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action. An additional focus will be the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level. The journal publishes full-length/mini reviews, original research articles and thematic issues on molecular pharmacology. Current Molecular Pharmacology is an essential journal for every scientist who is involved in drug design and discovery, target identification, target validation, preclinical and clinical development of drugs therapeutically useful in human disease.